KDM5A

  • Official Full Name

    lysine (K)-specific demethylase 5A

  • Overview

    Lysine-specific demethylase 5A is an enzyme that in humans is encoded by the KDM5A gene.<br/>The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which regulates cell proliferation. It was formally known as Retinoblastoma Binding Protein 2 (RBP2). This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. Rhombotin-2 is thought to either directly affect the activity of the encoded protein or may indirectly modulate the functions of the retinoblastoma protein by binding to this protein. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<br/>The Drosophila homolog, LID, was found to be an H3K4 histone demethylase that binds to c-Myc. It was recently renamed to Lysine Demethylase 5A (KDM5A).<br/>Enzymatically can be designated as a trimethyllysine dioxygenase.

  • Synonyms

    RBP2;RBBP2;RBBP-2;JARID1A;lysine-specific demethylase 5A;OTTHUMP00000237742;histone demethylase JARID1A;retinoblastoma binding protein 2;retinoblastoma-binding protein 2;jumonji/ARID domain-containing protein 1A;Jumonji, AT rich interactive domain 1A (RBP2-like);Jumonji, AT rich interactive domain 1A (RBBP2-like);KDM5A;lysine (K)-specific demethylase 5A

Recombinant Proteins

  • Human
  • Mouse
  • Sf9 Insect Cell
  • Wheat Germ
  • HEK293
  • Mammalian Cell
  • Yeast
  • E.coli
  • Flag
  • Non
  • His
  • His&Fc&Avi
  • His&SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
KDM5A-43H Active Recombinant Human KDM5A, FLAG-tagged Sf9 Insect Cell Human Flag
KDM5A-29894TH Recombinant Human KDM5A Wheat Germ Human Non 100 amino acids
KDM5A-683H Recombinant Human KDM5A Protein, DDK-tagged HEK293 Human Flag
KDM5A-8594M Recombinant Mouse KDM5A Protein Mammalian Cell Mouse His
KDM5A-1432H Recombinant Human KDM5A Protein (437-603 aa), His-tagged Yeast Human His 437-603 aa
KDM5A-4782M Recombinant Mouse KDM5A Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
KDM5A-4782M-B Recombinant Mouse KDM5A Protein Pre-coupled Magnetic Beads HEK293 Mouse
KDM5A-597H Recombinant Human KDM5A Protein (437-603 aa), His-SUMO-tagged E.coli Human His&SUMO 437-603 aa

    Involved Pathway

    KDM5A involved in several pathways and played different roles in them. We selected most pathways KDM5A participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chromatin modifying enzymes KDM4A,SUDS3,ANO9A,SMARCC1,KAT8,SMARCD3,COPRS,PRDM16,CHD4A,MORF4L1
    Chromatin organization MSL2B,USP22,JMJD6,PHF8,CAPNS2,PHF21A,SMARCE1,PADI1,BRMS1,MSL3
    HDMs demethylate histones KDM1A,KDM5C,KDM5BB,KDM3B,KDM5D,KDM3A,JHDM1D,KDM4D,PHF2,KDM6AL

    Protein Function

    KDM5A has several biochemical functions, for example, DNA binding,chromatin binding,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM5A itself. We selected most functions KDM5A had, and list some proteins which have the same functions with KDM5A. You can find most of the proteins on our site.

    Function Related Protein
    zinc ion binding ARIH2,TAF15,RXRB,TRIM25,MEP1B,CUL9,RNF185,RNF166,AGBL1,PAPLNB
    DNA binding IRX1A,STAT1A,ZBTB16,PROX2,SIX6A,TOX3,EMX3,NKX2-3,ZFP13,MEOX2B
    chromatin binding UPF1,GATA6,GATA3,PRDM13,TP53,RBPJ,PRKCBB,ARID3C,GABPA,NR5A1A
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors C14orf169,KDM5B,JHDM1D,KDM5C,EGLN3,TYW5,PHF8,EGLN1,ALKBH4,HIF1AN
    transcription coactivator activity MED14,MED12,GTF2A1L,EDF1,MTDH,CITED2,RBPMS,AIP,GRIP1,YAF2
    transcription factor activity, sequence-specific DNA binding TAF4B,ARNTL1A,FBXW7,BATF,ZNF256,ZNF812,ZFP639,CDX2,RUNX2A,GLIS2
    protein binding TBC1D9B,RPL37A,CAV1,FHL3,CDK13,TREX1,KCNE3,LBP,TRIM39,FARS2

    Interacting Protein

    KDM5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM5A here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM5A.

    CCT6A;h3_peptide_2-18;SIN3B;HDAC1;GATAD1;TM9SF4;PHF12;Rbm8a

    Resources

    References

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All KDM5A Products

    Required fields are marked with *

    My Review for All KDM5A Products

    Required fields are marked with *