KDM2A
-
Official Full Name
lysine (K)-specific demethylase 2A -
Overview
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] -
Synonyms
KDM2A;lysine (K)-specific demethylase 2A;FBL7;CXXC8;FBL11;FBXL11;JHDM1A;LILINA;lysine-specific demethylase 2A;F-box/LRR-repeat protein 11;CXXC-type zinc finger protein 8;[Histone-H3]-lysine-36 demethylase 1A;F-box and leucine-rich repeat protein 11;jumonji C domain-containing histone demethylase 1A;jmjC domain-containing histone demethylation protein 1A
Recombinant Proteins
- Human
- Rhesus macaque
- E.coli
- Insect Cell
- Sf9 Insect Cell
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- Flag&Avi
- His
- FLAG
- Non
- His&Fc&Avi
Involved Pathway
KDM2A involved in several pathways and played different roles in them. We selected most pathways KDM2A participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HDMs demethylate histones | PHF2,KDM4B,ARID5B,KDM5D,KDM2B,KDM5B,KDM3B,KDM1A,JMJD6,KDM5BA |
| Chromatin organization | RBBP5,KAT7,RBB4L,PRMT6,KDM4A,ZZZ3,YEATS4,MEAF6,PADI6,KDM5A |
| Chromatin modifying enzymes | SAP18,MBD3B,SMYD3,KDM5B,SMARCD3B,PADI1,MTA2,EP400,MTA1,MBD3A |
Protein Function
KDM2A has several biochemical functions, for example, histone demethylase activity (H3-K36 specific),unmethylated CpG binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM2A itself. We selected most functions KDM2A had, and list some proteins which have the same functions with KDM2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| unmethylated CpG binding | MLL1,DNMT3A,DNMT3B,CXXC1 |
| histone demethylase activity (H3-K36 specific) | C14orf169,PHF8,KDM8,JMJD5,KDM4A,KDM2B,JHDM1D |
| zinc ion binding | THRB,TCEA1,ZMIZ1,DTX1,PGLYRP6,SUV39H1A,NSMCE2,MUL1,LIN28B,EEA1 |
Interacting Protein
KDM2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM2A here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM2A.
h3_peptide_31-41;SKP1;SMAD7;FOS;ENO1;UBE2G2;SMAD3;phnP;FBXO32;ZNF512B;CBX4;BCL6;RAB5C;Cbx1;REEP5;KIF20B;Chmp4c;Skp1
Resources
Related Services
Related Products
References
- Huang, YF; Liu, YQ; et al. Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer. TUMOR BIOLOGY 36:271-278(2015).
- Kawakami, E; Tokunaga, A; et al. The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators. MECHANISMS OF DEVELOPMENT 135:31-42(2015).
