KCNN4
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Official Full Name
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 -
Overview
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008] -
Synonyms
KCNN4;potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4;IK1;SK4;KCA4;hSK4;IKCA1;hKCa4;KCa3.1;hIKCa1;intermediate conductance calcium-activated potassium channel protein 4;SKCa4;SKCa 4;putative Gardos channel;putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel
Recombinant Proteins
- Human
- Mouse
- Rat
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- His
- GST
- His&Fc&Avi
Involved Pathway
KCNN4 involved in several pathways and played different roles in them. We selected most pathways KCNN4 participated on our site, such as Ca2+ activated K+ channels,Insulin secretion,Neuronal System, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNN4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Salivary secretion | PRKCA,PLCB4,ITPR3,ATP2B4,PRH1,HTN1,PLCB3,PLCB1,BST1,CALML5 |
| Protein digestion and absorption | CELA2A,COL24A1,SLC36A1,COL13A1,LOC780933,ELN,ATP1B3,PRSS2,SLC1A1,COL7A1 |
| Potassium Channels | KCNK1,KCNH1A,KCNH5,KCNC3A,KCNG3,KCNQ2A,KCNK4,KCNA1,KCNS3A,KCNC1A |
| Insulin secretion | ATP1B3,PLCB3,CREB3L1,KCNN3,PRKACG,KCNMB1,GLP1R,RYR2,PRKACA,CAMK2G |
| Ca2+ activated K+ channels | KCNMA1,KCNMB2,KCNN1,KCNMB1,KCNN1A,KCNN1B,KCNN3,KCNN2 |
| Neuronal System | CAMKK1B,SLC18A3A,KCNC4,KCNH1A,KCNK10B,CHRNE,RERG,KCNG1,KCNA10,KCNB1 |
Protein Function
KCNN4 has several biochemical functions, for example, Intermediate conductance calcium-activated potassium channel activity,calcium-activated potassium channel activity,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNN4 itself. We selected most functions KCNN4 had, and list some proteins which have the same functions with KCNN4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | MYO3A,RYR1,MAPKAPK5,SLC8A2,MARCKSL1,CNN3A,PPP3CC,MAP2,CNN1A,RGS4 |
| protein binding | ATP5G1,PLAUR,MTX2,LAX1,PPP2R4,MKI67,U2AF2,SETBP1,VAV2,RCN2 |
| calcium-activated potassium channel activity | KCNMB4,KCNMB2,KCNK18,KCNT1,KCNMA1,HPN,MTMR6,KCNN1B,KCNN1A,KCNMB1 |
| protein phosphatase binding | CSK,PPARG,TRAF2,PIK3R1,ANAPC4,RPA3,DLG3,RPA2,LCK,NEK2 |
Interacting Protein
KCNN4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNN4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNN4.
CALM1;Calml3
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References
- Strobaek, D; Brown, DT; et al. NS6180, a new K(Ca)3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease. BRITISH JOURNAL OF PHARMACOLOGY 168:432-444(2013).
- Kim, U; Siegel, R; et al. Identification of transcription coactivator OCA-B-dependent genes involved in antigen-dependent B cell differentiation by cDNA array analyses. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100:8868-8873(2003).
- Hoffman, JF; Joiner, W; et al. The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100:7366-7371(2003).
