KCNMA1
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Official Full Name
potassium large conductance calcium-activated channel, subfamily M, alpha member 1 -
Overview
Calcium-activated potassium channel subunit alpha-1 also known as potassium large conductance calcium-activated channel, subfamily M, alpha member 1 (KCa1.1) is a voltage gated ion channel encoded by the KCNMA1 gene. KCa1.1 channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. -
Synonyms
KCNMA1;potassium large conductance calcium-activated channel, subfamily M, alpha member 1;SLO;calcium-activated potassium channel subunit alpha-1;BK channel alpha subunit;KCa1.1;mSLO1;hSlo;k(VCA)alpha;slo homolog;slowpoke homolog;BKCA alpha sub
Recombinant Proteins
- Rhesus macaque
- Rat
- Chicken
- Human
- Mammalian Cell
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
- His&HPC4
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KCNMA1-2364R | Recombinant Rhesus monkey KCNMA1 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| KCNMA1-3214R | Recombinant Rat KCNMA1 Protein | Mammalian Cell | Rat | His |
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| KCNMA1-5797C | Recombinant Chicken KCNMA1 | Mammalian Cell | Chicken | His |
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| KCNMA1-5028HCL | Recombinant Human KCNMA1 293 Cell Lysate | HEK293 | Human | Non |
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| KCNMA1-2185R | Recombinant Rhesus Macaque KCNMA1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| KCNMA1-2185R-B | Recombinant Rhesus Macaque KCNMA1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| KCNMA1-2703H | Recombinant Human KCNMA1 Protein (411-560 aa), His-HPC4-tagged | E.coli | Human | His&HPC4 | 411-560 aa |
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| KCNMA1-2870R | Recombinant Rat KCNMA1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| KCNMA1-2870R-B | Recombinant Rat KCNMA1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| KCNMA1-4378H | Recombinant Human KCNMA1 protein | E.coli | Human | Non | 411-560aa |
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Involved Pathway
KCNMA1 involved in several pathways and played different roles in them. We selected most pathways KCNMA1 participated on our site, such as Ca2+ activated K+ channels,Hemostasis,Insulin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNMA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ca2+ activated K+ channels | KCNN3,KCNN4,KCNN2,KCNMB1,KCNN1A,KCNN1,KCNMB2,KCNN1B |
| Nitric oxide stimulates guanylate cyclase | PDE10A,KCNMB1,KCNMB2 |
| Neuronal System | PANX1A,KCNN1A,Apba1,KCNF1A,CHRND,HCN4,GABRR2A,KCNJ1A.4,KCNQ2,KCNA1 |
| Pancreatic secretion | ATP2A2,PNLIPRP2,SLC9A1,ATP1A1,RAC1,AMY2A4,PLA2G12B,CTRB1,CPA2,CPA1 |
| Hemostasis | PDE10A,F3A,KIF4,KIF20A,DOCK11,PHF21A,PROCA,SPARC,KIF9,PDPN |
| Insulin secretion | STX1A,PLCB3,ATP1A2,KCNN2,KCNMB1,GPR119,ATP1B2,PRKCG,SLC2A2,GLP1R |
| Potassium Channels | KCNJ14,KCNK2B,KCNQ2,KCNS3,KCNK1,KCND1,KCNAB2,KCNJ1A.5,KCNJ1A.2,KCND2 |
| Platelet homeostasis | ATP2B3A,SLC8A2A,PDE10A,KCNMB1,KCNMB2,ATP2B1B,APOER2 |
Protein Function
KCNMA1 has several biochemical functions, for example, actin binding,calcium-activated potassium channel activity,large conductance calcium-activated potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNMA1 itself. We selected most functions KCNMA1 had, and list some proteins which have the same functions with KCNMA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | FGD4,ZFP191,TRIM35-35,AGFG2,BMX,ACSM2B,ZFP12,ZSCAN4C,NT5C2B,ACY1 |
| large conductance calcium-activated potassium channel activity | KCNMA1A |
| protein binding | TNNI1,TUFM,LRRK1,UBE2D2,RUNX2,HMGB4,KIF9,CTSB,HMGB2,KRTAP3-3 |
| voltage-gated potassium channel activity | KCNH6A,KCNC1,KCNH2A,KCNA4,KCNMA1A,KCNAB3,KCNK9,KCNC4,CNGA5,KCNAB2B |
| calcium-activated potassium channel activity | KCNK18,KCNN2,KCNMA1A,HPN,KCNMB2,MTMR6,KCNT1,CCT8L2,PKD2L1,KCNN1 |
| actin binding | WASH1,ACTN4,MSRB1,KLHL2,MYOT,MYO1G,DIAPH3,MSNB,MSNA,SYN1 |
Interacting Protein
KCNMA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNMA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNMA1.
KCNMB2;ALB
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References
- Pyott, SJ; Glowatzki, E; et al. Extrasynaptic localization of inactivating calcium-activated potassium channels in mouse inner hair cells. JOURNAL OF NEUROSCIENCE 24:9469-9474(2004).
