KCNK4
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Official Full Name
potassium channel, subfamily K, member 4 -
Overview
Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The encoded protein homodimerizes and functions as an outwardly rectifying channel. It is expressed primarily in neural tissues and is stimulated by membrane stretch and polyunsaturated fatty acids. -
Synonyms
KCNK4;potassium channel, subfamily K, member 4;potassium channel subfamily K member 4;K2p4.1;TRAAK;MGC144821;K2P4.1 potassium channel;KCNK 4;Potassium inwardly rectifying channel subfamily K member 4;TRAAK1;TRAAKt;TWIK related arachidonic acid stimulated potassium channel protein;Two pore K+ channel KT4.1;two pore K(+) channel KT4.1;two pore potassium channel KT4.1;TWIK-related arachidonic acid-stimulated potassium channel protein
Recombinant Proteins
- Mouse
- Human
- Mus musculus
- Mammalian Cell
- HEK293
- HEK293T
- E.coli
- E.coli expression system
- His
- Non
- Myc&DDK
- GST
- His&Fc&Avi
Involved Pathway
KCNK4 involved in several pathways and played different roles in them. We selected most pathways KCNK4 participated on our site, such as Neuronal System,Potassium Channels,TWIK related potassium channel (TREK), which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tandem pore domain potassium channels | KCNK1B,KCNK2,KCNK1,DDX1,KCNK1A,KCNK13B,KCNK2B,KCNK13A,KCNK6,KCNK18 |
| TWIK related potassium channel (TREK) | KCNK2B,KCNK2,KCNK10B |
| Neuronal System | KCNH1,RERG,KCNQ1,KCNJ14,AKAP5,KCNK2,SLC17A7A,GLS2B,KCNQ2A,CACFD1 |
| Potassium Channels | KCNN1B,KCNH1B,KCNV2,KCNH6,KCNG3,KCNN1,KCNV1,KCNK16,KCNN4,KCNJ8 |
Protein Function
KCNK4 has several biochemical functions, for example, mechanically-gated potassium channel activity,potassium channel activity,potassium ion leak channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNK4 itself. We selected most functions KCNK4 had, and list some proteins which have the same functions with KCNK4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| temperature-gated cation channel activity | TRPA1 |
| potassium ion leak channel activity | KCNK13B,KCNK10B,KCNK5A,KCNK10,KCNK1B,KCNK9,KCNK2,KCNK5B,KCNK1,TMEM175 |
| potassium channel activity | DDX1,KCNQ3,KCNC3A,KCNV2,KCNK1B,KCNQ4,KCNQ2A,KCNK5A,KCNK16,KCNS3B |
| voltage-gated ion channel activity | CACNG8A,KCNK16,CLIC5,CYBB,CALHM1,CACNG7A,KCNJ2A,CACNA1SA,KCNJ11L,CATSPER2 |
Interacting Protein
KCNK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNK4.
RPL14;DIDO1
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References
- Wu, J; Wu, X; et al. Overexpression of potassium channel ether a go-go1 in human osteosarcoma. NEOPLASMA 59:207-215(2012).
- Wang, L; Fyffe, REW; et al. Identification of a kv3.4 channel in corneal epithelial cells. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 45:1796-1803(2004).
