KCNK2
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Official Full Name
KCNK2 potassium channel, subfamily K, member 2 -
Overview
Potassium channel subfamily K member 2 is a protein that in humans is encoded by the KCNK2 gene. This gene encodes K2P2.1, one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. -
Synonyms
KCNK2;potassium channel, subfamily K, member 2;potassium channel subfamily K member 2;K2p2.1;TREK 1;K2P2.1 potassium channel;TREK-1 K(+) channel subunit;two-pore potassium channel 1;TWIK-related potassium channel 1;two pore potassium channel TPKC1;two pore domain potassium channel TREK-1;tandem-pore-domain potassium channel TREK-1;outward rectifying potassium channel protein TREK-1;potassium inwardly-rectifying channel, subfamily K, member 2;TREK;TPKC1;TREK1;TREK-1;hTREK-1c;hTREK-1e;MGC126742;MGC126744
Recombinant Proteins
- Human
- Mus musculus
- HEK293
- Yeast
- E.coli expression system
- Non
- His
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KCNK2-5035HCL | Recombinant Human KCNK2 293 Cell Lysate | HEK293 | Human | Non |
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| KCNK2-5036HCL | Recombinant Human KCNK2 293 Cell Lysate | HEK293 | Human | Non |
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| KCNK2-1850H | Recombinant Human KCNK2 Protein, His-tagged | Yeast | Human | His |
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| KCNK2-96HCL | Recombinant Human KCNK2 Lysate | HEK293 | Human | Myc&DDK |
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| KCNK2-97HCL | Recombinant Human KCNK2 Lysate | HEK293 | Human | Myc&DDK |
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| RFL30733MF | Recombinant Full Length Mouse Potassium Channel Subfamily K Member 2(Kcnk2) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-411) |
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| RFL35325HF | Recombinant Full Length Human Potassium Channel Subfamily K Member 2(Kcnk2) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-426) |
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Involved Pathway
KCNK2 involved in several pathways and played different roles in them. We selected most pathways KCNK2 participated on our site, such as Gastric acid secretion,Neuronal System,Potassium Channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TWIK related potassium channel (TREK) | KCNK4,KCNK10B,KCNK2B |
| Tandem pore domain potassium channels | KCNK1,KCNK1A,KCNK2B,KCNK10B,DDX1,KCNK13B,KCNK6,KCNK4,KCNK7,KCNK16 |
| Gastric acid secretion | ATP1A4,PLCB1,SSTR2,Slc4a2,PRKACA,CAMK2G,Adcy4,ATP1B4,CALML3,ATP1A2 |
| Neuronal System | KCNC1A,KCNA7,KCNH2A,KCNN2,CPLX1,SYN3,KCNJ1A.6,CHRND,SNAP25B,UNC13B |
| Potassium Channels | KCNK2B,KCNK13B,KCNJ1A.1,KCNC1A,KCNA2,KCNG1,KCNH2,KCNK1A,KCNJ1A.2,DDX1 |
Protein Function
KCNK2 has several biochemical functions, for example, outward rectifier potassium channel activity,potassium channel inhibitor activity,potassium ion leak channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNK2 itself. We selected most functions KCNK2 had, and list some proteins which have the same functions with KCNK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| potassium channel inhibitor activity | KCNA5,ENSA,CAV3,PTI,RASA1,NEDD4L |
| potassium ion leak channel activity | KCNK7,KCNK1A,KCNK13B,KCNK3,KCNK5A,KCNK1B,KCNK10B,KCNK9,KCNK2B,KCNK18 |
| outward rectifier potassium channel activity | REST,KCNB1,KCNK1A,KCNK2B,KCNK18,KCNA5,KCNK5B,KCNQ1 |
Interacting Protein
KCNK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNK2.
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References
- Tang, GH; Wang, Y; et al. G(o)2 G protein mediates galanin inhibitory effects on insulin release from pancreatic beta cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109:2636-2641(2012).
- O'Grady, SM; Lee, SY; et al. Molecular diversity and function of voltage-gated (Kv) potassium channels in epithelial cells. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 37:1578-1594(2005).
