KCNJ5
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Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 5 -
Overview
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. -
Synonyms
KCNJ5;potassium inwardly-rectifying channel, subfamily J, member 5;G protein-activated inward rectifier potassium channel 4;CIR;GIRK4;KATP1;Kir3.4;IRK-4;heart KATP channel;inward rectifier K+ channel KIR3.4;cardiac ATP-sensitive potassium channe
Recombinant Proteins
- Rat
- Mouse
- Human
- Sus scrofa (Pig)
- Mus musculus
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
KCNJ5 involved in several pathways and played different roles in them. We selected most pathways KCNJ5 participated on our site, such as Activation of G protein gated Potassium channels,Activation of GABAB receptors,Calcium Regulation in the Cardiac Cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNJ5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of G protein gated Potassium channels | GNB3B,KCNJ3,KCNJ9,KCNJ6,GNGT2A,KCNJ2A,GNGT2B,KCNJ10,KCNJ4,GNB3A |
| G protein gated Potassium channels | KCNJ9,GNGT2A,KCNJ2A,KCNJ12,GNB3A,KCNJ4,KCNJ15,KCNJ2,GNGT2B,KCNJ6 |
| Estrogen signaling pathway | AKT2,SRC,FKBP4,GRB2,SP1,PIK3R3,ESR1,CALM4,KRAS,HSPA6 |
| Dopaminergic synapse | GRIA4,GNAI3,GNB4,PPP2R5E,GNG11,KIF5B,GNG8,KCNJ6,GNAQ,PPP2CB |
| Activation of GABAB receptors | GNGT2A,ADCY7,KCNJ3,KCNJ2,ADCY1,ADCY6,KCNJ6,KCNJ12,GNGT2B,GNB3A |
| GABA B receptor activation | KCNJ10,GNGT2A,KCNJ2,KCNJ15,KCNJ12,KCNJ6,GNB3A,KCNJ9,GNGT2B,KCNJ4 |
| Circadian entrainment | GRIN2A,RYR3,MAPK3,RYR1,GRIA3,PLCB1,GUCY1A3,PRKACA,GRIN2D,GNAI3 |
| Calcium Regulation in the Cardiac Cell | RGS17,RGS20,YWHAQ,ADRB2,RGS14A,GJB6,RGS5,CHRM1,ADRA1B,CHRM4 |
Protein Function
KCNJ5 has several biochemical functions, for example, G-protein activated inward rectifier potassium channel activity,contributes_to inward rectifier potassium channel activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNJ5 itself. We selected most functions KCNJ5 had, and list some proteins which have the same functions with KCNJ5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to inward rectifier potassium channel activity | KCNE2,KCNJ3 |
| G-protein activated inward rectifier potassium channel activity | KCNJ6,KCNJ9,KCNJ3 |
| protein binding | PCDH18B,SEC31A,ZFP346,FBXL5,NKX3,ACCS,IGFL1,THEM5,VAPA,CPEB4 |
Interacting Protein
KCNJ5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNJ5 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNJ5.
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References
- Kuppusamy, M; Caroccia, B; et al. A Novel KCNJ5-insT149 Somatic Mutation Close to, but Outside, the Selectivity Filter Causes Resistant Hypertension by Loss of Selectivity for Potassium. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:E1765-E1773(2014).
