KCNJ11
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Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 11 -
Overview
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009] -
Synonyms
KCNJ11;potassium inwardly-rectifying channel, subfamily J, member 11;BIR;HHF2;PHHI;IKATP;TNDM3;KIR6.2;ATP-sensitive inward rectifier potassium channel 11;beta-cell inward rectifier subunit;inward rectifier K(+) channel Kir6.2;inwardly rectifying potassium channel KIR6.2;potassium channel inwardly rectifing subfamily J member 11;potassium channel, inwardly rectifying subfamily J member 11
Recombinant Proteins
- Rhesus macaque
- Human
- Rat
- Zebrafish
- Guinea pig
- Mus musculus
- Oryctolagus cuniculus (Rabbit)
- Mammalian Cell
- Wheat Germ
- E.Coli or Yeast
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
KCNJ11 involved in several pathways and played different roles in them. We selected most pathways KCNJ11 participated on our site, such as ABC-family proteins mediated transport,ATP sensitive Potassium channels,FOXA2 and FOXA3 transcription factor networks, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNJ11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inwardly rectifying K+ channels | ABCC9,KCNJ1A.6,KCNJ1A.2,KCNJ1B,KCNJ8,KCNJ2A,GNGT2A,KCNJ1A.1,KCNJ10,KCNJ1 |
| ABC-family proteins mediated transport | ABCG4B,ABCC2,ABCA4A,EIF2S3,ABCA7,ABCE1,ABCD3B,ABCF1,ABCC9,ABCA8 |
| Integration of energy metabolism | KCNB1,ARL2BP,KCNS3A,RAPGEF3,AKAP5,GNG13B,SYT5,KCNC2,GNB5A,RAPGEF4 |
| Metabolism | CYP3A7-CYP3AP1,GLTPD1,SUMF2,TREH,TPH2,SACM1LA,DPYS,CYP3A7,AGL,CES1 |
| ATP sensitive Potassium channels | ABCC9,KCNJ8 |
| Neuronal System | CHRNA7,KCNK2B,SLC6A11,SLC1A2B,KCNJ8,SLC6A1A,KCNAB2,KCNG1,KCNQ2A,KCNV1 |
| FOXA2 and FOXA3 transcription factor networks | CPT1A,CEBPA,DLK1,CPT1C,FOXA1,CPT1B,FOXF1,TTR,UCP2 |
| Insulin secretion | VAMP2,PLCB4,STX1A,RAB3A,KCNMB3,ATP1B4,CREB3L1,ATP1A3,SLC2A2,ATP1B3 |
Protein Function
KCNJ11 has several biochemical functions, for example, ATP binding,ATP-activated inward rectifier potassium channel activity,NOT G-protein activated inward rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNJ11 itself. We selected most functions KCNJ11 had, and list some proteins which have the same functions with KCNJ11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein C-terminus binding | ERCC4,BLOC1S2,NEFL,TRIM3,OPRL1,DYNLL1,ERCC3,TFCP2,SAE1,DDX1 |
| NOT G-protein activated inward rectifier potassium channel activity | KCNJ8,KCNJ11L |
| ankyrin binding | FLNC,KCTD6,ATP1A1,SPTBN1,SLC4A1,PTBP3,OBSCN,RHAG,PLEC,RHCG |
| ATP binding | GK2,MYO5A,NRK,AK8,PRKY,MAPK14,PRKACAB,STK38L,KATNAL1,PRKCBB |
| ATP-activated inward rectifier potassium channel activity | KCNJ10,KCNJ1A.1,KCNJ1A.4,KCNJ11L,KCNJ1A.6,KCNJ1A.3,KCNJ8,KCNJ1A.2,KCNJ1B,KCNJ1 |
| voltage-gated potassium channel activity | KCNA6,KCNC3A,CNGA1,HCN2,KCNC3B,KCNQ5,KCNK5,KCNT1,KCNQ3,KCNE4 |
| potassium ion binding | SLC24A4A,PKM,HDAC4,PKMB,KCNA4,SLC24A1,SLC24A2,PKMA,PKM2,SLC24A4 |
| ion channel binding | PKD1,GPD1L,KCNE1L,SCN5A,DIAP1,ACTN1,LYN,RANGRF,HOMER1,FYN |
| heat shock protein binding | PACRG,BAX,DNAJC9,PPID,NFKBIA,TPR,CDC37,HSPA1L,DNAJA4,DNAJA3 |
Interacting Protein
KCNJ11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNJ11 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNJ11.
ABCC9;Kcnj11;ugpC
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References
- Irgens, HU; Molnes, J; et al. Prevalence of monogenic diabetes in the population-based Norwegian Childhood Diabetes Registry. DIABETOLOGIA 56:1512-1519(2013).
- Alves, C; Constanca, J; et al. A novel atypical presentation of insulin autoimmune syndrome (Hirata's disease) in a child. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 26:1163-1166(2013).
