KCNJ10
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Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 10 -
Overview
This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. -
Synonyms
KCNJ10;potassium inwardly-rectifying channel, subfamily J, member 10;ATP-sensitive inward rectifier potassium channel 10;Kir1.2;Kir4.1;inwardly rectifying subfamily J member 10;ATP dependent inwardly rectifying potassium channel Kir4.1;ATP sensitive inward rectifier potassium channel 10;ATP-dependent inwardly rectifying potassium channel Kir4.1;BIRK10;Glial ATP dependent inwardly rectifying potassium channel KIR4.1;Inward rectifier K(+) channel Kir1.2;Inward rectifier K+ channel KIR1.2;Inwardly rectifying potassium channel Kir1.2;IRK10_HUMAN;KCNJ 10;KCNJ13 PEN;Potassium channel;Potassium channel inwardly rectifying subfamily J member 10;Potassium inwardly rectifying channel subfamily J member 10;SESAME;OTTHUMP00000025748;potassium channel, inwardly rectifying subfamily J me;BIRK-10;KCNJ13-PEN
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Mus musculus
- E.coli
- Mammalian Cell
- HEK293T
- Wheat Germ
- E.Coli or Yeast
- HEK293
- In vitro E. coli expression system
- E.coli expression system
- His
- GST
- Myc&DDK
- His&SUMO
- Non
- His&Fc&Avi
Involved Pathway
KCNJ10 involved in several pathways and played different roles in them. We selected most pathways KCNJ10 participated on our site, such as Activation of G protein gated Potassium channels,Activation of GABAB receptors,G protein gated Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNJ10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | KCNJ2A,GNGT2A,GNGT2B,KCNJ15,KCNJ4,KCNJ12 |
| GABA B receptor activation | GNB3A,GNGT2A,KCNJ15,GNGT2B,KCNJ2A,KCNJ4,KCNJ6,KCNJ9,KCNJ2,KCNJ5 |
| Gastric acid secretion | ATP1B4,SLC26A7,CALM2,ITPR1,PRKCA,CA2,PLCB1,ATP4A,KCNJ16,KCNJ15 |
| Activation of G protein gated Potassium channels | KCNJ15,KCNJ2,KCNJ9,GNB3A,KCNJ4,GNB3B,KCNJ3,KCNJ5,KCNJ6,KCNJ12 |
| GABA receptor activation | KCNJ4,KCNJ2,GABRR2A,GNGT2B,GNGT2A,KCNJ9,KCNJ15,GNB3A,KCNJ2A,KCNJ12 |
| Inwardly rectifying K+ channels | KCNJ15,GNGT2B,KCNJ14,KCNJ11,KCNJ1A.4,GNGT2A,KCNJ1,ABCC9,KCNJ2A,KCNJ1A.3 |
| Activation of GABAB receptors | GNGT2B,KCNJ2,KCNJ4,ADCY9,GNGT2A,KCNJ6,ADCY3,GNB3B,ADCY8,KCNJ15 |
| G protein gated Potassium channels | GNGT2B,KCNJ6,KCNJ4,KCNJ15,GNGT2A,GNB3B,GNB3A,KCNJ2,KCNJ9,KCNJ2A |
Protein Function
KCNJ10 has several biochemical functions, for example, ATP binding,ATP-activated inward rectifier potassium channel activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNJ10 itself. We selected most functions KCNJ10 had, and list some proteins which have the same functions with KCNJ10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | G6PDX,TRP53,TRIP10,ALAD,COL2A1,LRRK1,KIRRELA,TRADD,HSP90AA1,HAPLN2 |
| receptor binding | DAO,PVRL1B,FGF13A,POU2F1,TNFSF10,CXCL10,MPV17L,ABL2,RARA,SERPINE1 |
| ATP binding | TRPM4,TGFBR1B,NRBP1,UBE2D2A,ERN1,EPHA4B,KIF18B,DARS2,TK2,ATP13A5 |
| protein binding | ZNF622,S100B,C7orf59,ADRM1,ASPH,GPN3,NR2F2,N6AMT1,GFM1,ORAI2 |
| ATP-activated inward rectifier potassium channel activity | KCNJ8,KCNJ1A.1,KCNJ1B,KCNJ1A.5,KCNJ1,KCNJ11,KCNJ1A.4,KCNJ1A.6,KCNJ11L,KCNJ1A.2 |
Interacting Protein
KCNJ10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNJ10 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNJ10.
SIAH1;KCNJ16;MAGI1;Magi1;MAGI1;ouabain
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