KCNJ1
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Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 1 -
Overview
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
KCNJ1;potassium inwardly-rectifying channel, subfamily J, member 1;ROMK;ROMK1;KIR1.1;ATP-sensitive inward rectifier potassium channel 1;inwardly rectifying K+ channel;inward rectifier K(+) channel Kir1.1;ATP-regulated potassium channel ROM-K;potassium channel, inwardly rectifying subfamily J member 1
Recombinant Proteins
- Human
- Rat
- Mouse
- Mus musculus
- Wheat Germ
- Mammalian Cell
- E.Coli or Yeast
- HEK293
- Yeast
- E.coli
- E.coli expression system
- Non
- His
- His&Fc&Avi
Involved Pathway
KCNJ1 involved in several pathways and played different roles in them. We selected most pathways KCNJ1 participated on our site, such as Aldosterone-regulated sodium reabsorption,Gastric acid secretion,Inwardly rectifying K+ channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNJ1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gastric acid secretion | CALM3,CAMK2D,CAMK2G,SLC9A4,KCNJ15,GAST,MYLK2,CA2,ATP1B1,CAMK2A |
| Potassium Channels | KCNG1,KCNQ3,KCNS3,KCNK3A,KCNC1B,KCNJ1A.2,KCNH1,HCN4,KCNJ1A.1,KCNAB3 |
| Neuronal System | KCNA1,SLC6A11,KCNK1,KCND3,KCNH1B,KCNC1,GRIP1,KCNN1A,CPLX2L,KCNH1 |
| Aldosterone-regulated sodium reabsorption | PIK3R5,HSD11B2,ALPHA-ENAC,IGF1,ATP1A4,SFN,SCNN1B,INS1,NEDD4L,PDPK1 |
| Inwardly rectifying K+ channels | KCNJ1A.6,KCNJ1A.1,KCNJ10,GNGT2A,KCNJ2A,KCNJ1A.3,GNGT2B,ABCC9,KCNJ8,KCNJ1A.4 |
| Potassium transport channels | KCNJ1B,KCNJ1A.1,KCNJ1A.4,KCNJ1A.5,KCNJ1A.2,KCNJ1A.6,KCNJ1A.3 |
Protein Function
KCNJ1 has several biochemical functions, for example, ATP binding,ATP-activated inward rectifier potassium channel activity,inward rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNJ1 itself. We selected most functions KCNJ1 had, and list some proteins which have the same functions with KCNJ1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol-4,5-bisphosphate binding | SLC9A1,RS1,TIRAP,FCHO2,SNX18,FAM123A,LDLRAP1,ADAP2,COMMD1,SNX21 |
| inward rectifier potassium channel activity | KCNJ11L,KCNJ1A.1,KCNJ6,KCNK1,KCNJ2,KCNJ1A.4,KCNJ1A.2,KCNJ4,KCNK6,KCNJ15 |
| ATP-activated inward rectifier potassium channel activity | KCNJ11L,KCNJ1A.2,KCNJ10,KCNJ1B,KCNJ1A.3,KCNJ1A.6,KCNJ11,KCNJ1A.5,KCNJ1A.1,KCNJ8 |
| ATP binding | MAP2K2,HSPA13,ABCA6,DCLK1A,CCT8,ADCY9,ATP13A4,ADCK1,EPHA1,ACTR2 |
Interacting Protein
KCNJ1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNJ1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNJ1.
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