KCNIP4
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Official Full Name
KCNIP4 Kv channel interacting protein 4 -
Overview
Kv channel-interacting protein 4 is a protein that in humans is encoded by the KCNIP4 gene. This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. -
Synonyms
KCNIP4;Kv channel interacting protein 4;Kv channel-interacting protein 4;CALP;KCHIP4;MGC44947;calsenilin-like protein;potassium channel interacting protein 4;potassium channel-interacting protein 4;a-type potassium channel modulatory protein 4
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
KCNIP4 involved in several pathways and played different roles in them. We selected most pathways KCNIP4 participated on our site, such as Regulation of Wnt-mediated beta catenin signaling and target gene transcription, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNIP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Wnt-mediated beta catenin signaling and target gene transcription | CBY1,MYOG,TLE2,IGF2BP1,AES,CYR61,SALL4,T,ZCCHC12,TCF4 |
Protein Function
KCNIP4 has several biochemical functions, for example, calcium ion binding,potassium channel activity,potassium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNIP4 itself. We selected most functions KCNIP4 had, and list some proteins which have the same functions with KCNIP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| potassium channel activity | TMEM38B,KCNIP1,KCNC1B,AQP1,KCNK3,KCNC1A,KCNS3A,TRPM5,KCNK10,KCNV2 |
| potassium channel regulator activity | KCNE2,KCNMB4,KCNE3,SGK2B,DPP6,AMIGO1,NEDD4L,ABCC9,CHP,SGK2A |
| calcium ion binding | CALM3A,ANXA13L,ANXA11B,PCDHB14,EFCAB10,DSG1C,GCH1,PCDH2AB8,PLS3,GSNB |
| voltage-gated ion channel activity | CACNG7A,KCNJ1A.2,CX35B,KCNC3A,CLIC5,CLIC3,KCNV2B,PKD2,KCNB2,CACNG8A |
Interacting Protein
KCNIP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNIP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNIP4.
FAM120B;KCNIP2
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