KCNIP1
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Official Full Name
Kv channel interacting protein 1 -
Overview
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms. -
Synonyms
KCNIP1;Kv channel interacting protein 1;Kv channel-interacting protein 1;KCHIP1;vesicle APC-binding protein;potassium channel interacting protein 1;potassium channel-interacting protein 1;A-type potassium channel modulatory protein 1;VABP;MGC95
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KCNIP1-3225H | Recombinant Human KCNIP1 protein, His-tagged | E.coli | Human | His | 1-216 aa |
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| KCNIP1-28452TH | Recombinant Human KCNIP1, His-tagged | E.coli | Human | His | 15-214 a.a. |
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| KCNIP1-3190R | Recombinant Rat KCNIP1 Protein | Mammalian Cell | Rat | His |
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| KCNIP1-8506M | Recombinant Mouse KCNIP1 Protein | Mammalian Cell | Mouse | His |
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| KCNIP1-5056HCL | Recombinant Human KCNIP1 293 Cell Lysate | HEK293 | Human | Non |
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| KCNIP1-2846R | Recombinant Rat KCNIP1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| KCNIP1-2846R-B | Recombinant Rat KCNIP1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Kcnip1-3657M | Recombinant Mouse Kcnip1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| KCNIP1-4734M | Recombinant Mouse KCNIP1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| KCNIP1-4734M-B | Recombinant Mouse KCNIP1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
KCNIP1 involved in several pathways and played different roles in them. We selected most pathways KCNIP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNIP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
KCNIP1 has several biochemical functions, for example, calcium ion binding,ion channel binding,potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNIP1 itself. We selected most functions KCNIP1 had, and list some proteins which have the same functions with KCNIP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | C1rb,TMPRSS6,PCLO,GUCA1C,PVALB8,SYTL4,FAM20C,THBS4,PCDH2G4,TNNC1 |
| ion channel binding | NOS1,SRC,KCNC1,RIMS3,LRRK2,CHERP,PKD2,CTNNB1,USP10,PKD1 |
| protein binding | C1S,TRIM15,KPNB1,VAPA,XPO7,GTF2H2C,IL18R1,FAN1,ANKRD32,CCNB1 |
| protein N-terminus binding | MAU2,SUV39H1,SLA2,SMARCA4,PEX5,TGFB1,SMARCE1,ID1,BIRC2,HESX1 |
| potassium channel regulator activity | SGK1,YWHAE,KCNMB4,ANK2,ARPP19A,KCNS3,KCNAB2,SGK2A,KCNAB1,DLG1 |
| protein heterodimerization activity | BCL2,TAF13,TP53,BCL2A,SOX6,HMG20B,H3F3A,SPTA1,TAS1R2,ALX4 |
| voltage-gated ion channel activity | KCNC1A,KCNA2B,CACNA1SB,KCNIP3,KCNF1A,KCNC3A,KCNC2,TMEM37,SCN8AA,KCNB2 |
| potassium channel activity | KCNQ4,KCNH6A,KCNS3B,KCNC3B,KCNK16,KCNC1A,KCNK4,KCNA2,KCNK2B,KCNC4 |
Interacting Protein
KCNIP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNIP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNIP1.
KCND3;KCND2;calcium(2+)
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References
- Menegola, M; Clark, E; et al. The importance of immunohistochemical analyses in evaluating the phenotype of Kv channel knockout mice. EPILEPSIA 53:142-149(2012).
- Choudhury, S; Schnell, M; et al. Antibodies Against Potassium Channel Interacting Protein 2 Induce Necrosis in Isolated Rat Cardiomyocytes. JOURNAL OF CELLULAR BIOCHEMISTRY 115:678-689(2014).
