KCNH1

  • Official Full Name

    potassium voltage-gated channel, subfamily H (eag-related), member 1

  • Overview

    Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.

  • Synonyms

    KCNH1;potassium voltage-gated channel, subfamily H (eag-related), member 1;potassium voltage-gated channel subfamily H member 1;eag;eag1;h eag;Kv10.1;Voltage gated potassium channel subunit Kv10.1;MGC124420;MGC142269;EAG channel 1;Ether a go go potassium channel 1;Ether-a-go-go potassium channel 1;h-eag;hEAG1;KCNH1_HUMAN;M eag;MGC124419;Potassium voltage gated channel subfamily H (eag related), member 1;Voltage-gated potassium channel subunit Kv10.1;OTTHUMP00000034451;OTTHUMP00000034569;ether-a-go-go, Drosophila, homolog of

Recombinant Proteins

  • Rhesus macaque
  • Human
  • Rat
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
KCNH1-2353R Recombinant Rhesus monkey KCNH1 Protein, His-tagged Mammalian Cell Rhesus macaque His
KCNH1-29891TH Recombinant Human KCNH1 Wheat Germ Human Non 99 amino acids
KCNH1-3182R Recombinant Rat KCNH1 Protein Mammalian Cell Rat His
KCNH1-5060HCL Recombinant Human KCNH1 293 Cell Lysate HEK293 Human Non
KCNH1-2174R Recombinant Rhesus Macaque KCNH1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
KCNH1-2174R-B Recombinant Rhesus Macaque KCNH1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
KCNH1-2838R Recombinant Rat KCNH1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
KCNH1-2838R-B Recombinant Rat KCNH1 Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    KCNH1 involved in several pathways and played different roles in them. We selected most pathways KCNH1 participated on our site, such as Neuronal System,Potassium Channels,Voltage gated Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Voltage gated Potassium channels KCNG4A,KCNF1,KCNS3,KCNB2,KCNAB2B,KCNC4,KCNH6A,KCNF1A,KCNAB1A,KCNG1
    Potassium Channels KCNMB1,KCNC2,KCNS3A,KCNK2,KCNA6A,KCNJ14,KCNH5,KCNA2,KCNK1,KCNN2
    Neuronal System KCNG3,KCNS3A,CACNG2B,KCNN1,KCNV1,KCNK1,KCNA6,GJA10,SNAP25B,KCNK7

    Protein Function

    KCNH1 has several biochemical functions, for example, 14-3-3 protein binding,calmodulin binding,NOT cyclic nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNH1 itself. We selected most functions KCNH1 had, and list some proteins which have the same functions with KCNH1. You can find most of the proteins on our site.

    Function Related Protein
    ion channel binding CAV1,RIMS1,FAM115C,FGF13,YWHAQ,PDE4D,SCN3B,CALM2,FAM115A,PRNP
    delayed rectifier potassium channel activity KCNV2,KCNS3A,KCNA2B,KCNF1A,KCNQ1,KCNB1,KCNQ2A,KCNC1B,KCNC2,KCNA10
    protein heterodimerization activity LIFR,TYR,HIST2H2L,OSTA,LIMK1,GRIN2A,TIRAP,RAF1,SYT14,HIST1H2AF
    calmodulin binding PLA2G6,ADD2,PDE1C,TRPV4,SNTA1,MYO1G,MYH11,SLC14A2,GRIN1,CAMK2B1
    14-3-3 protein binding HDAC7,IRS2,PRKCZ,RPTOR,PRKCE,HDAC7A,AKT1,YWHAQ,TSC2,DDIT4
    protein binding BCL7A,PROC,ELF2,DLX2,GKAP1,AHSA2,PIGS,DUSP5,NME4,TRPS1
    phosphorelay sensor kinase activity KCNH1A,KCNH8,KCNH2,CASS4,KCNH5,KCNH5A,KCNH1B
    protein kinase binding TRAF4,LSM2,RFFL,PPP1CC,GCSAM,PTPN6,LLGL1,PLCG1,B4GALT1,PKD1

    Interacting Protein

    KCNH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNH1.

    CALM1;SDCBP;FASTKD5;WDYHV1;S100B;Rabep1;Kcnh1;RAB7A

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