HUWE1
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Official Full Name
HECT, UBA and WWE domain containing 1 -
Overview
This gene encodes a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed. Mutations in this gene has been found in 3 unrelated families with X-linked syndromic mental retardation, Turner type. -
Synonyms
HUWE1;HECT, UBA and WWE domain containing 1;E3 ubiquitin-protein ligase HUWE1;Ib772;KIAA0312;UREB1;UBA and WWE domain-containing protein 1;ARF binding protein 1;ARF BP1;ARF-binding protein 1;ARF-BP1;E3 ubiquitin protein ligase HUWE1;HECT;HECT UBA and WWE domain containing protein 1;HectH9;Homologous to E6AP carboxyl terminus homologous protein 9;HUWE;HUWE1_HUMAN;KIAA1578;Large structure of UREB1;LASU1;Mcl 1 ubiquitin ligase E3;Mcl-1 ubiquitin ligase E3;MULE;Upstream regulatory element-binding protein 1;URE B1;URE-B1;URE-binding protein 1;UREB 1;OTTHUMP00000023356;OTTHUMP00000023357;BJ-HCC-24 tumor antigen;HECT domain protein LASU1;HECT, UBA;HSPC272
Recombinant Proteins
- Human
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- GST
- His
- His&Fc&Avi
- N-His&C-Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HUWE1-14016H | Recombinant Human HUWE1, GST-tagged | E.coli | Human | GST | C-term-392a.a. | |
| HUWE1-136H | Recombinant Human HUWE1, GST-tagged | E.coli | Human | GST | 3760-4374 a.a. |
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| HUWE1-14015H | Recombinant Human HUWE1, GST-tagged | Wheat Germ | Human | GST |
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| HUWE1-2179R | Recombinant Rhesus monkey HUWE1 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| HUWE1-2000R | Recombinant Rhesus Macaque HUWE1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| HUWE1-2000R-B | Recombinant Rhesus Macaque HUWE1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| HUWE1-4016H | Recombinant Human HUWE1 protein(4005-4374aa), His&Myc-tagged | E.coli | Human | N-His&C-Myc | 4005-4374aa |
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Involved Pathway
HUWE1 involved in several pathways and played different roles in them. We selected most pathways HUWE1 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HUWE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immune System | FBXO17,KIF22,NLRP4C,RNF135,CMTM2A,DTX3L,ATG7,AP1S3A,RNF19B,DYNC1LI2 |
| Antigen processing: Ubiquitination & | ASB4,PJA1,ASB8,KLHL21,RNF144B,PJA2,FBXO44,CMTM2A,ATG7,ARIH2 |
| Ubiquitin mediated proteolysis | PIAS1,FBXW8,FBXW11,CUL4B,MGRN1B,BIRC3,HERC3,SAE1,HERC4,NEDD4 |
| presentation | UBA5,ASB17,BLMH,ASB14,UBE2V2,CYBB,SPSB1,UBE2L6,PJA2,FBXO17 |
| Proteasome degradation | RNF19B,KLHL21,PJA1,SPSB1,TPP2,ASB10,PJA2,KLHL20,RNF220,TRAF7 |
| Adaptive Immune System | KIF18A,UBR1,AGO2,SPSB1,AGO1,IGKC,RNF111,AGO3,FGF20A,CD200R2 |
| p53 pathway | NEDD8,CSE1L,KAT8,TRIM28,DYRK2,E4F1,TTC5,SMYD2,PPP1R13L,CSNK1G3 |
| Validated targets of C-MYC transcriptional activation | IREB2,PRDX3,PDCD10,MTDH,CDCA7,MYCT1,LIN28B,SERPINI1,PEG10,MINA |
| Class I MHC mediated antigen processing & | RNF19B,HECTD3,ATG7,SPSB1,UBE2J2,FBXO17,ASB13,LTN1,ARIH2,TRAF7 |
Protein Function
HUWE1 has several biochemical functions, for example, DNA binding,ligase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HUWE1 itself. We selected most functions HUWE1 had, and list some proteins which have the same functions with HUWE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | PEBP1,PRPF3,RPL35,PUF60,PURB,PUM1,WDR3,XRCC5,LAS1L,ELAVL1 |
| ubiquitin-protein transferase activity | BRAP,SIAH2L,TRAF4A,UHRF2,RBBP6,KLHL20,FBXO4,CDC23,UBE2E3,RNF4 |
| DNA binding | ETS1,TMEM18,ZFY2,ZFP654,ASCL1A,FOXE3,FOXN1,NR5A1,RABGEF1L,HOXD3 |
| ubiquitin protein ligase activity | RAG2,ANAPC11,AMFR,MED20,HECTD1,ANKIB1,NHLRC1,UBE3A,FANCF,RNF121 |
| ligase activity | MKRN2,FPGS,TRAF2,PCXA,LTN1,MYLIPB,TRIM71,HERC4,UBE2G1A,RFWD2 |
| protein binding | TUBA3E,PRC1,DPP3,KIF22,PEG10,IRF1,NOLC1,PTGDR,EFTUD2,C19orf60 |
Interacting Protein
HUWE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HUWE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HUWE1.
MCL1;CDKN2A;USP7;TP53;HSPB1;vif
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