HUS1
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Official Full Name
HUS1 checkpoint homolog -
Overview
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. -
Synonyms
HUS1;HUS1 checkpoint homolog (S. pombe);HUS1 (S. pombe) checkpoint homolog;checkpoint protein HUS1;hus1+ like protein;hus1+-like protein;hHUS1
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&SUMO
- His&Fc&Avi
- GST
Involved Pathway
HUS1 involved in several pathways and played different roles in them. We selected most pathways HUS1 participated on our site, such as Activation of ATR in response to replication stress,Cell Cycle,Cell Cycle Checkpoints, which may be useful for your reference. Also, other proteins which involved in the same pathway with HUS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of ATR in response to replication stress | CHEK1,DBF4,RAD17,MCM8,MCM10,CLSPN,RAD9B,RAD9A,CDK2,RAD1 |
| G2/M Checkpoints | BRCC3,RNF168,RAD9B,UIMC1,FAM175A,THRSP,RAD9,RAD9A,RAD1,BRE |
| Cell Cycle Checkpoints | RAD50,THRSP,BABAM1,CHEK1,MCM10,BRCC3,HTATIP,RAD9A,CHEK2,KAT5 |
| HDR through Homologous Recombination (HRR) | EME2,TOPBP1,KIAA0146,RTEL1,RBBP8,RHNO1,WRN,RAD9B,FUZ,GEN1 |
| DNA Double-Strand Break Repair | TDP2,BRE,CHEK1,TIPIN,FUZ,RAD51AP1,KDM4A,WRN,KDM4B,UIMC1 |
| DNA Repair | PPIE,ERCC8,COPS2,RIF1,PNKP,DTL,GPS1,COPS4,INO80E,TIPIN |
| HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) | RNF168,UIMC1,RAD1,EME2,KIAA0146,RAD9B,TOPBP1,GEN1,TIMELESS,RTEL1 |
| Cell cycle | PMF1,ANAPC13,MCM7,SYNE1,CDKN2A,GADD45A,SGOL1,CENPJ,NUP50,CCDC99 |
Protein Function
HUS1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HUS1 itself. We selected most functions HUS1 had, and list some proteins which have the same functions with HUS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PRSS2,MAU2,ZCCHC8,PRKX,EFEMP2,PDZD7,CUL3,FKBP1A,VAC14,LIPE |
Interacting Protein
HUS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HUS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HUS1.
RAD1;RAD9A;PSD;HPRT1;ALDOB;PSMA2;YWHAZ;STRAP;CD200
Resources
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References
- Bozdarov, J; Sherry, JP; et al. The rad1 gene in Rainbow Trout (Oncorhynchus mykiss) is highly conserved and may express proteins from non-canonical spliced isoforms. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 157:16-23(2013).
- Saberi, A; Nakahara, M; et al. The 9-1-1 DNA clamp is required for immunoglobulin gene conversion. MOLECULAR AND CELLULAR BIOLOGY 28:6113-6122(2008).
