HTR3E
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Official Full Name
5-hydroxytryptamine (serotonin) receptor 3, family member E -
Overview
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes a subunit E of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3. An alternative splice variant has been described but its full length sequence has not been determined. -
Synonyms
HTR3E;5-hydroxytryptamine (serotonin) receptor 3, family member E;5-hydroxytryptamine receptor 3E;5-HT-3;5-HT3 receptor subunit E splice variant HTR3Ea;5-HT3c1;5-HT3E;5-HT3R;5-hydroxytryptamine receptor 3 subunit E;5HT3c1;5HT3E;5HT3R;HTR3;MGC120035;MGC120036;MGC120037;SEROTONIN 5-HT-3E RECEPTOR;serotonin receptor 3 subunit E;Serotonin receptor 3E;5-HT3-E
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HTR3E-5332HCL | Recombinant Human HTR3E 293 Cell Lysate | HEK293 | Human | Non |
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| HTR3E-2714H | Recombinant Human HTR3E Transmembrane protein (72-228 aa & 241-456 aa), His-SUMO-tagged | In vitro E. coli expression system | Human | His&SUMO | 72-228aa&241-456aa |
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Involved Pathway
HTR3E involved in several pathways and played different roles in them. We selected most pathways HTR3E participated on our site, such as Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR3E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Serotonergic synapse | CYP2C70,PLCB2,GNG4,CYP2C55,HTR1B,PRKCG,KCND2,PRKACG,ALOX5,CYP2C39 |
Protein Function
HTR3E has several biochemical functions, for example, NOT contributes_to acetylcholine binding,NOT contributes_to acetylcholine receptor activity,NOT contributes_to acetylcholine-activated cation-selective channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR3E itself. We selected most functions HTR3E had, and list some proteins which have the same functions with HTR3E. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT contributes_to acetylcholine receptor activity | HTR3A,HTR3B,HTR3C |
| protein binding | TLK2,LRSAM1,SUPT4H1,DIEXF,ILF2,RYR2,DHX15,FSTL1,HNRNPA1,ZNF10 |
| serotonin-activated cation-selective channel activity | HTR3C,HTR3B,HTR3A |
| NOT contributes_to acetylcholine binding | HTR3B,HTR3A,HTR3C |
| NOT contributes_to acetylcholine-activated cation-selective channel activity | HTR3B,HTR3C,HTR3A |
| serotonin receptor activity | HTR6,HTR1F,HTR1A,HTR1AA,HTR3C,HTR2C,HTR1E,HTR2B,HTR5A,HTR2A |
Interacting Protein
HTR3E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR3E here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR3E.
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References
- Lennertz, L; Wagner, M; et al. 5-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option. EUROPEAN NEUROPSYCHOPHARMACOLOGY 24:86-94(2014).
- Xu, Z; Zhang, ZJ; et al. Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response. JOURNAL OF PSYCHOPHARMACOLOGY 26:349-359(2012).
