HTR3A
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Official Full Name
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic -
Overview
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] -
Synonyms
HTR3A;5-hydroxytryptamine (serotonin) receptor 3A, ionotropic;HTR3;5HT3R;5-HT-3;5-HT3A;5-HT3R;5-hydroxytryptamine receptor 3A;5-HT3-A;serotonin receptor 3A;5HT3 serotonin receptor;5-hydroxytryptamine receptor 3;serotonin-gated ion channel receptor
Recombinant Proteins
- Rat
- Human
- Guinea pig
- Mus musculus
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HTR3A-2965R | Recombinant Rat HTR3A Protein | Mammalian Cell | Rat | His |
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| HTR3A-5334HCL | Recombinant Human HTR3A 293 Cell Lysate | HEK293 | Human | Non |
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| HTR3A-2620R | Recombinant Rat HTR3A Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| HTR3A-2620R-B | Recombinant Rat HTR3A Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| HTR3A-5240H | Recombinant Human HTR3A Protein | Wheat Germ | Human | Non |
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| HTR3A-5690HF | Recombinant Full Length Human HTR3A Protein | In Vitro Cell Free System | Human | Full L. 573 amino acids |
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| RFL17450RF | Recombinant Full Length Rat 5-Hydroxytryptamine Receptor 3A(Htr3A) Protein, His-Tagged | E.coli expression system | Rat | His | Full L. Full Length of Mature Protein (24-483) |
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| RFL19833HF | Recombinant Full Length Human 5-Hydroxytryptamine Receptor 3A(Htr3A) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length of Mature Protein (24-478) |
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| RFL28389CF | Recombinant Full Length Guinea Pig 5-Hydroxytryptamine Receptor 3A(Htr3A) Protein, His-Tagged | E.coli expression system | Guinea pig | His | Full L. Full Length of Mature Protein (20-490) |
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| RFL36307MF | Recombinant Full Length Mouse 5-Hydroxytryptamine Receptor 3A(Htr3A) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length of Mature Protein (24-487) |
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Involved Pathway
HTR3A involved in several pathways and played different roles in them. We selected most pathways HTR3A participated on our site, such as Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Serotonergic synapse | GABRB2,TPH1,ITPR1,GNAI3,CYP2C50,MAOA,HTR2C,KRAS,SLC6A4,BRAF |
Protein Function
HTR3A has several biochemical functions, for example, NOT contributes_to acetylcholine binding,NOT contributes_to acetylcholine receptor activity,NOT contributes_to acetylcholine-activated cation-selective channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR3A itself. We selected most functions HTR3A had, and list some proteins which have the same functions with HTR3A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT contributes_to acetylcholine receptor activity | HTR3B,HTR3C,HTR3E |
| serotonin binding | HTR1B,MAOA,HTR1E,HTR1F,HTR2B,HTR2A,HTR2C |
| serotonin-activated cation-selective channel activity | HTR3B,HTR3E,HTR3C |
| NOT contributes_to acetylcholine binding | HTR3C,HTR3E,HTR3B |
| protein binding | LENG1,AMPD2,DLX2,CHRM3,FAM156A,NGF,SH3GL3,FGFBP1,PAX5,ITGA2 |
| voltage-gated potassium channel activity | HCN2,CNGA3,KCNAB2B,KCNC1B,KCNAB1,CNGA2,KCNA6,KCNQ3,KCNA2B,KCNH6 |
| receptor activity | CD226,EXTL3,SMAGP,VMN1R46,VAC14,APLNR,P2RY1,KIR2DL1,ADIPOR1A,SLC1A5 |
| serotonin receptor activity | HTR5A,HTR3B,HTR2B,HTR2A,HTR1E,HTR1A,HTR1F,HTR1AA,HTR1B,HTR2C |
| NOT contributes_to acetylcholine-activated cation-selective channel activity | HTR3B,HTR3C,HTR3E |
Interacting Protein
HTR3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR3A here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR3A.
HTR3E;HTR3D;HTR3C;HTR3E;HTR3B
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