HTR1B
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Official Full Name
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled -
Overview
The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.[supplied by OMIM, Oct 2009] -
Synonyms
HTR1B;5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled;S12;5-HT1B;HTR1D2;HTR1DB;5-HT1DB;5-hydroxytryptamine receptor 1B;5-HT-1B;5-HT-1D-beta;serotonin receptor 1B;serotonin 1D beta receptor
Recombinant Proteins
- Human
- Rat
- Chicken
- Zebrafish
- Mouse
- Spalax ehrenbergi (Middle East blind mole rat) (Nannospalax ehrenbergi)
- Guinea pig
- Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)
- Mus musculus
- Felis catus
- Oryctolagus cuniculus (Rabbit)
- Gorilla gorilla gorilla (Western lowland gorilla)
- Cricetulus griseus
- Vulpes vulpes (Red fox)
- Dog
- Horse
- Pan troglodytes
- E.coli
- Mammalian Cell
- HEK293
- In vitro E. coli expression system
- Insect Cell
- Wheat Germ
- E.coli expression system
- His
- Non
- His&Flag
- His&Fc&Avi
- His&SUMO
- GST
Involved Pathway
HTR1B involved in several pathways and played different roles in them. We selected most pathways HTR1B participated on our site, such as cAMP signaling pathway,Neuroactive ligand-receptor interaction,Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | MC4R,PPYR1,F2RL3,GRM8,PRL2,F2RL1.2,PTGER2B,F2RL2,PTGDR,VIPR2 |
| cAMP signaling pathway | ATP1B3,HTR6,PIK3R2,GRIA1,PLD1,PDE4A,GABBR2,PPP1CA,BAD,BRAF |
| Serotonergic synapse | ALOX8,HTR3E,CYP2C54,PRKACG,MAOA,SLC18A2,KRAS,PRKACB,Casp3,GNB2 |
Protein Function
HTR1B has several biochemical functions, for example, drug binding,protein binding,serotonin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR1B itself. We selected most functions HTR1B had, and list some proteins which have the same functions with HTR1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serotonin binding | HTR2A,HTR3A,HTR1E,HTR1F,HTR2B,HTR2C,MAOA |
| drug binding | HTR2A,PNP,SMO,PPP3CA,SRP54B,DRD1,MT2A,CHRNB2,DAAM2,FASN |
| protein binding | NMU,PPIC,SULT1E1,RBL2,BAIAP2,POLDIP2,RFX3,SLX4,DDX58,SYT2 |
| serotonin receptor activity | HTR3B,HTR2B,HTR2A,HTR6,HTR3A,HTR1A,HTR2CL1,HTR1E,HTR7,HTR3E |
Interacting Protein
HTR1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR1B here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR1B.
MDFI;serotonin;iodocyanopindolol/cyp;HTR1A;NME2;GSTK1
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