HTR1A
-
Official Full Name
5-hydroxytryptamine (serotonin) receptor 1A -
Overview
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the;5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and;pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and;stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic;fevers. -
Synonyms
HTR1A;5-hydroxytryptamine (serotonin) receptor 1A;5-hydroxytryptamine receptor 1A;5 HT1A receptor;5 HT 1A;5 HT receptor 1A;5 HT1A;5 hydroxytryptamine (serotonin) receptor 1A;5 hydroxytryptamine receptor 1A;5-HT-1A;5-HT1A;5HT 1A;5HT 1A receptor;5HT receptor 1A;5HT1A_HUMAN;ADRB2RL1;ADRBRL1;G 21;G protein coupled receptor;G-21;Gpcr 18;Gpcr18;Guanine nucleotide binding regulatory protein-coupled receptor;Serotonin 1A receptor;Serotonin 5HT1A receptor;Serotonin receptor 1A;5HT1A;RAT5HT1A
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Dog
- Pongo Pygmaeus
- Mus musculus
- Gorilla gorilla gorilla (Western lowland gorilla)
- Xenopus laevis
- Pan troglodytes
- Horse
- Vulpes vulpes (Red fox)
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- E.coli expression system
- His
- Non
- GST
- His&Flag
- His&Fc&Avi
Involved Pathway
HTR1A involved in several pathways and played different roles in them. We selected most pathways HTR1A participated on our site, such as cAMP signaling pathway,Neuroactive ligand-receptor interaction,Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | GIPR,CALM2,CAMK2G,PTGER3,PIK3CD,GRIA3,RHOA,PIK3R1,ATP1A2,PDE4C |
| Serotonergic synapse | MAPK1,CYP2C55,PLCB2,PRKACB,PLCB4,APP,CYP4X1,HTR2A,HTR1E,PTGS2 |
| Neuroactive ligand-receptor interaction | GABRA3,MC1R,GRIA2,TAAR12I,TAAR14J,TAAR5,P2RY10,TRHR2,FPR3,HCRTR1 |
Protein Function
HTR1A has several biochemical functions, for example, protein binding,serotonin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR1A itself. We selected most functions HTR1A had, and list some proteins which have the same functions with HTR1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ERCC2,SMAD5,LAX1,GTF3C4,HOXB7,CD1A,HERC5,ZBTB17,NDUFS3,BDKRB2 |
| serotonin receptor activity | HTR3A,HTR1D,HTR6,HTR2CL1,HTR7,HTR3E,HTR1E,HTR1AA,HTR2C,HTR2B |
Interacting Protein
HTR1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR1A here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR1A.
Resources
Related Services
Related Products
References
- Matthews, PR; Harrison, PJ; et al. A morphometric, immunohistochemical, and in situ hybridization study of the dorsal raphe nucleus in major depression, bipolar disorder, schizophrenia, and suicide. JOURNAL OF AFFECTIVE DISORDERS 137:125-134(2012).
- Xu, J; Zhang, GL; et al. Hypomethylation of the HTR1A promoter region and high expression of HTR1A in the peripheral blood lymphocytes of patients with systemic lupus erythematosus. LUPUS 20:678-689(2011).
