HSPG2
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Official Full Name
heparan sulfate proteoglycan 2 -
Overview
PLC (Phosphoinositide-specific phospholipase C) plays a significant role in transmembrane signaling. Four PLC family members have been identified: PLCbeta, PLCgamma, PLCDelta, and PLCEpsilon. In response to extracellular stimuli (e.g., hormone, growth fac -
Synonyms
HSPG2;heparan sulfate proteoglycan 2;Schwartz Jampel syndrome 1 (chondrodystrophic myotonia) , SJS1;basement membrane-specific heparan sulfate proteoglycan core protein;perlecan;perlecan proteoglycan;PRCAN;endorepellin (domain V region);PLC;SJA
Recombinant Proteins
- Human
- Mouse
- Chicken
- NS0
- CHO
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293T
- Insect Cell
- HEK293
- His
- Non
- Myc&DDK
- His&Myc
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HSPG2-01H |
Active Recombinant Human HSPG2 protein, His-tagged
|
NS0 | Human | His |
|
|
| HSPG2-02M |
Active Recombinant Mouse HSPG2 protein, His-tagged
|
CHO | Mouse | His |
|
|
| HSPG2-1178C | Recombinant Chicken HSPG2 | Mammalian Cell | Chicken | His |
|
|
| HSPG2-29309TH | Recombinant Human HSPG2 | Wheat Germ | Human | Non | 110 amino acids |
|
| HSPG2-8046H | Recombinant Human HSPG2 protein, His-tagged | E.coli | Human | His | Leu4149~Ser4391 |
|
| HSPG2-03H | Recombinant Human HSPG2 Protein, His-Tagged | E.coli | Human | His |
|
|
| HSPG2-05HCL | Recombinant Human HSPG2 Over-expression Lysate, C-Myc/DDK tagged | HEK293T | Human | Myc&DDK |
|
|
| HSPG2-2230H | Recombinant Human HSPG2 protein, His&Myc-tagged | Insect Cell | Human | His&Myc | 4197-4391aa |
|
| HSPG2-5026H | Recombinant Human HSPG2 protein, His&Myc-tagged | HEK293 | Human | His&Myc | 4197-4391aa |
|
| HSPG2-5262H | Recombinant Human HSPG2 Protein, GST-tagged | Wheat Germ | Human | GST |
|
Involved Pathway
HSPG2 involved in several pathways and played different roles in them. We selected most pathways HSPG2 participated on our site, such as ECM-receptor interaction,Hepatitis B,Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ECM-receptor interaction | COL6A1,COL4A4,COL2A1B,ITGB5,GP1BA,ITGA2B,LAMC2,TNR,GP9,DAG1 |
| Proteoglycans in cancer | AKT1,HGF,NANOG,WNT4,WNT9B,ERBB4,TP53,MAPK13,RPS6KB1,FZD10 |
| Hepatitis B | ATF4,IKBKE,TGFBR1,STAT5A,Casp3,IFNA17,VDAC3,SRC,DDX3X,CREB3L2 |
Protein Function
HSPG2 has several biochemical functions, for example, metal ion binding,protein C-terminus binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPG2 itself. We selected most functions HSPG2 had, and list some proteins which have the same functions with HSPG2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | POLB,ZNF384L,GLI2B,NDUFS2,MYBPC3,MICALL2A,ZNF483,RACGAP1,FHL1B,AEBP2 |
| protein C-terminus binding | ERBB2,YWHAB,PCGF1,TAF13,ERCC2,TCF4,ATF4,SAE1,SIRT1,ATP2A2 |
| protein binding | DTX2,PITPNM3,STX11,SPATA8,KIAA1191,OBSCN,EP300,TDGF1,ALDH18A1,CCDC41 |
Interacting Protein
HSPG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPG2.
KDR;GRN;FLT1;Npnt;FGF1;FGF2;FGFR1;FGFR3;CACNA1A;TCAP;ATN1
HSPG2 Related Signal Pathway
Resources
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References
- Brown, AJ; Alicknavitch, M; et al. Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation. BONE 43:689-699(2008).
- Hayes, AJ; Gibson, MA; et al. Confocal microscopy demonstrates association of LTBP-2 in fibrillin-1 microfibrils and colocalisation with perlecan in the disc cell pericellular matrix. TISSUE & CELL 46:185-197(2014).
