HSPA6
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Official Full Name
heat shock 70kDa protein 6 (HSP70B′) -
Overview
The Hsp70 system is a highly conserved family of ubiquitous proteins found in all prokaryotes and in cellular compartments of eukaryotic organisms. Multiple members of this family are involved in protein folding and several other cellular functions. Some forms are constitutively expressed in cells, while others are only inducible by metabolic stress. Various stressors that induce Hsp70 include heat shock, hypoxia, UV irradiation, CdCl2 and arsenite. Basal levels of constitutive Hsp70 are found in major intracellular compartments and the inducible Hsp70s are predominantly cytoplasmic and nuclear in distribution. There are at least 11 genes for proteins of the human Hsp70 family, which code for a group of highly related proteins ranging from 66 to 78 kDa. The multiple members of this family vary with their basal expression levels and inducibility in response to different stressors. The Hsp70 chaperones have two major functional domains. The highly conserved NH2-terminal domain has ATPase activity and binds to ADP and ATP very tightly, and COOH-terminal binds to polypeptides. Hsp70 is known to bind preferentially to unfolded and partially folded proteins and prevent their aggregation or misfolding. The nomenclature of the different members of Hsp70 family is extensive and is based on cellular distribution and inducibility (refer to Appendix VI, page 24, for nomenclature of Hsp70 family members).<br/>Human HSP70B′ is a variant Hsp70 that is more basic than the major Hsp70 and has different stress-induction characteristics. There have been several reports of Hsp70 variants, but most of them are products of different postranslational modifications. HSP70B′ is a product of a separate gene which is devoid of introns similar to Hsp70. The HSP70B′ gene has 77% sequence identity to Hsp70 gene and 70% identity to Hsc70 cDNA with highest sequence divergence at the 3'- end. Promoter studies have shown HSP70B′ to be a unique member of the Hsp70 family. Unlike Hsp70 which shows basal levels of expression and is induced by heat and various stressors, HSP70B′ is strictly heat-inducible and shows no basal levels. One study reported the use of HSP70B′ as a target gene for studying single nucleotide?polymorphisms (SNP) in biopsy samples of human prostate cancer patients. -
Synonyms
HSPA6;heat shock 70kDa protein 6 (HSP70B′);heat shock 70kD protein 6 (HSP70B′);heat shock 70 kDa protein 6;heat shock 70 kDa protein B
Recombinant Proteins
- Human
- E.coli
- Yeast
- Wheat Germ
- HEK293
- Mammalian cells
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
HSPA6 involved in several pathways and played different roles in them. We selected most pathways HSPA6 participated on our site, such as Spliceosome,MAPK signaling pathway,Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | HSP90AA1,UBE2E1,DNAJB1A,CRYABA,CALRL2,BAK1,UBE2G1A,ERP29,UBE2G1B,UBQLNL |
| Estrogen signaling pathway | HSP90AA1,GNAS,CALML3,PIK3R2,CALM1,SOS1,CREB3L2,FKBP4,OPRM1,HSPA1A |
| Endocytosis | CCR5,CSF1R,ZFYVE9,CHMP4C,PIP5K1A,SNF8,HRAS,IL2RGA,TGFBR1A,BC2 |
| Toxoplasmosis | BIRC7,HLA-DOB,PDPK1,LAMA2,MAPK12,MAPK9,CYCS,Toxoplasma Gondii Major Surface Antigen P30,MAP2K6,H2-AB1 |
| Legionellosis | C3,HSPA1A,SAR1A,IL1B,NAIP6,RAB1B,IL12A,NLRC4,IL12B,NFKB1 |
| MAPK signaling pathway | CACNA1BA,HRAS,MEF2CB,CACNA1G,GADD45B,MAPKAPK2A,NFKB2,MEF2CA,GNG12A,CACNB3 |
| Antigen processing and presentation | HLA-DPB1,TAPBP,CALR,KLRD1,HLA-DQA1,TNF,B2M,KIR3DL1,HLA-DRA,NFYB |
| Measles | PIK3CA,IFNA4,DDX58,TLR4,STAT3,IRAK1,AKT1,BBC3,IFNA1,PIK3R5 |
| Influenza A | MAPK1,HLA-DQA2,BCL2L2-PABPN1,IL12A,Ifna15,MAPK8,PIK3CA,MAP2K3,NLRX1,AGFG1 |
Protein Function
HSPA6 has several biochemical functions, for example, ATP binding,ATPase activity, coupled,NF-kappaB binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA6 itself. We selected most functions HSPA6 had, and list some proteins which have the same functions with HSPA6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| unfolded protein binding | CHAF1A,HSP90AA1,SYVN1,SRSF10,CDC37,PPIA,CRYABB,HSP90AA1.1,DNAJA2L,CALR |
| heat shock protein binding | DMPK,GRXCR2,GPR37,IRAK1,DNAJA4,APAF1,CDC37,DNAJA3A,TOMM34,HSPA9 |
| ATPase activity, coupled | HSP104,HSPA8,ABCB1A,MYH3,HSPA1B,PEX1,NSF,VPS4B,CCT8,VPS4A |
| protease binding | PYCARD,SERPINE1,TTN,TRP53,TIMP2A,FAP,TIMP3,DVL3,ADAMTSL4,SERPINB6 |
| enzyme binding | HNRNPUL1,DYM,CNTNAP2,PCCA,SCNM1,RCOR3,VAPB,C6orf211,CBX3,HDAC10 |
| NF-kappaB binding | RPS3,MTDH,FOXP3,CDKN2A,SNAI1A,COMMD7,HIF1AN,BCL10,TAF4B,CPNE1 |
| protein binding | MID1,RPL27A,NANOS2,FZD5,MYO1E,REEP5,MRPL15,HTT,TFAP2C,ID1 |
| ATP binding | PDIK1L,ERCC6L,ACVR2A,RIPK2,KIFC3,TXK,P2RX4B,SNRKA,STK40,MINK1 |
Interacting Protein
HSPA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA6.
TERF1;NFKB2;RIPK2;TNFRSF1A;TNFRSF1B;RELB;REL;MAP3K1;TAB1;MAP3K14;MAP3K3;STUB1;IKBKG;ADCK5;gerSC;CYP4F12;CISH;DNAJB4;2_aha_camp
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