HSPA13
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Official Full Name
heat shock protein 70kDa family, member 13 -
Overview
The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein. -
Synonyms
HSPA13;heat shock protein 70kDa family, member 13;STCH, stress 70 protein chaperone, microsome associated, 60kD , stress 70 protein chaperone, microsome associated, 60kDa;heat shock 70 kDa protein 13;HSP13_HUMAN;MGC133835;Microsomal stress 70 protein ATPase core;Microsomal stress-70 protein ATPase core;Stress 70 protein chaperone microsome associated 60 kDa protein;Stress-70 protein chaperone microsome-associated 60 kDa protein;stress 70 protein chaperone, microsome-associated, 60kD;stress 70 protein chaperone, microsome-associated, 60kDa;STCH
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
HSPA13 involved in several pathways and played different roles in them. We selected most pathways HSPA13 participated on our site, such as Cellular response to heat stress,Cellular responses to stress,Regulation of HSF1-mediated heat shock response, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cellular responses to stress | HIRA,TXN,HIST2H3C,NUP50,DYNLL2,PTGES3,H3F3D,HMGA1-RS1,WIPI1,HIF3A |
| Regulation of HSF1-mediated heat shock response | BAG3,DNAJB6,RPS19BP1,HSPA12B,DNAJC7,HSPA7,KIAA1967,BAG5,HSPH1,C11orf73 |
| Cellular response to heat stress | HSBP1B,NUP35,EEF1A1,DNAJB6,HSPA7,C11orf73,NUPL2,PTGES3,BAG3,DNAJC7 |
Protein Function
HSPA13 has several biochemical functions, for example, ATP binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA13 itself. We selected most functions HSPA13 had, and list some proteins which have the same functions with HSPA13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ABCA9,SRPK1,SMARCA5,ITK,ERBB3,ULK1,P2RX7,PFKL,KATNAL1,ALPK1 |
| protein binding | AFG3L2,GRIN3A,FAM118B,CARD10,MPZL1,SHC3,SPANXC,FBN2,PSMA3,TOR1B |
Interacting Protein
HSPA13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA13 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA13.
UBQLN1;SGTA;UBQLN1;SSR1;BAG6;RMI1;POLE4;UBQLN4;cona_canen;env
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References
- Brown, CA; Schmidt, C; et al. In vitro screen of prion disease susceptibility genes using the scrapie cell assay. HUMAN MOLECULAR GENETICS 23:5102-5108(2014).
- Lloyd, SE; Mead, S; et al. Genetics of prion diseases. CURRENT OPINION IN GENETICS & DEVELOPMENT 23:345-351(2013).
- Zhu, YF; Ren, CL; et al. Gene expression of Hsp70, Hsp90 and Hsp110 families in normal palate and cleft palate during mouse embryogenesis. TOXICOLOGY AND INDUSTRIAL HEALTH 29:915-930(2013).
- Grizenkova, J; Akhtar, S; et al. Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109:13722-13727(2012).
