HSD3B7
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Official Full Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 -
Overview
This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to neonatal cholestasis, a form of progressive liver disease. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
HSD3B7;hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7;3 beta-hydroxysteroid dehydrogenase type 7;C(27) 3BETA HSD;SDR11E3;short chain dehydrogenase/reductase family 11E;member 3;BB098564;OTTMUSP00000018895;OTTMUSP00000018897;3 beta HSD VII;3 beta hydroxy Delta(5) C27 steroid oxidoreductase;3 beta hydroxysteroid dehydrogenase type 7;3 beta hydroxysteroid dehydrogenase type VII;AI195443;C(27) 3 beta HSD;Cca2;Cholest 5 ene 3 beta,7 alpha diol 3 beta dehydrogenase;Confluent 3Y1 cell associated 2;Hydroxy delta 5 steroid dehydrogenase, 3 betaand steroid delta isomerase 7;OTTMUSP00000018894;PFIC4;3-beta-HSD VII;C(27)-3BETA-HSD;c(27) 3-beta-HSD;OTTHUMP00000163254;3 beta-hydroxysteroid dehydrogenase type VII;3 beta-hydroxy-delta 5-C27-steroid oxidoreductase;3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase;cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase;short chain dehydrogenase/reductase family 11E, member 3
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mus musculus
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
HSD3B7 involved in several pathways and played different roles in them. We selected most pathways HSD3B7 participated on our site, such as Primary bile acid biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD3B7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ATP5G3,PKMA,COX6A2,DGKE,CDIPT,PDXP,DHDPSL,B3GNT2B,MAT2A,ACSM5 |
| Primary bile acid biosynthesis | AKR1D1,CYP8B1,CYP46A1.3,CYP46A1,CYP39A1,CYP7A1A,HSD17B4,CH25H,AMACR,CH25HL2 |
Protein Function
HSD3B7 has several biochemical functions, for example, 3-beta-hydroxy-delta5-steroid dehydrogenase activity,cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD3B7 itself. We selected most functions HSD3B7 had, and list some proteins which have the same functions with HSD3B7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ATP6V1C1,CLK4,DOT1L,RAB3A,SNAPC5,FLNA,NR2E3,VENTX,CLSTN2,KLB |
| 3-beta-hydroxy-delta5-steroid dehydrogenase activity | SDR42E1,HSD3B5,NSDHL,HSD3B4,HSD3B6,HSD3B1,HSD3B2 |
Interacting Protein
HSD3B7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD3B7 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD3B7.
SPRY2;KRTAP10-7;KRTAP10-8;KRTAP10-9;NOTCH2NL
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References
- Harini, C; Sainath, SB; et al. Recovery of suppressed male reproduction in mice exposed to progesterone during embryonic development by testosterone. REPRODUCTION 137:439-448(2009).
- THOMAS, JL; FRIEDEN, C; et al. AN NADH-INDUCED CONFORMATIONAL CHANGE THAT MEDIATES THE SEQUENTIAL 3-BETA-HYDROXYSTEROID DEHYDROGENASE/ISOMERASE ACTIVITIES IS SUPPORTED BY AFFINITY LABELING AND THE TIME-DEPENDENT ACTIVATION OF ISOMERASE. JOURNAL OF BIOLOGICAL CHEMISTRY 270:21003-21008(1995).
