HSD17B7
-
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 7 -
Overview
HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the;biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol;(Marijanovic et al., 2003 (PubMed 12829805)). -
Synonyms
HSD17B7;hydroxysteroid (17-beta) dehydrogenase 7;3-keto-steroid reductase;PRAP;SDR37C1;short chain dehydrogenase/reductase family 37C;member 1;17 beta HSD 7;17 beta hydroxysteroid dehydrogenase 7;17 beta hydroxysteroid dehydrogenase type VII;17-beta-HSD 7;17-beta-hydroxysteroid dehydrogenase 7;17beta hydroxysteroid dehydrogenase;3 keto steroid reductase;DHB7_HUMAN;Estradiol 17 beta dehydrogenase 7;Estradiol 17-beta-dehydrogenase 7;hydroxysteroid (17 beta) dehydrogenase 7;MGC12523;MGC75018;Short chain dehydrogenase/reductase family 37C member 1;17 beta-hydroxysteroid dehydrogenase type VII;short chain dehydrogenase/reductase family 37C, member 1
Recombinant Proteins
- Rat
- Zebrafish
- Chicken
- Human
- Cynomolgus
- Mouse
- Mus musculus
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
HSD17B7 involved in several pathways and played different roles in them. We selected most pathways HSD17B7 participated on our site, such as Steroid biosynthesis,Steroid hormone biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD17B7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ovarian steroidogenesis | INS1,HSD3B6,PRKACB,INS,HSD17B1,HSD3B1,INSR,ALOX5,LHCGR,LHB |
| Metabolic pathways | DOLK,GGT6,CYP2C19,GPI,PIK3C3,GLS2,RFK,POLR2C,QDPRB2,CSGALNACT1 |
| Steroid hormone biosynthesis | HSD3B1,SULT2B1,HSD3B4,HSD17B12B,CYP11C1,CYP21A1,SRD5A2A,SULT1E1,CYP2C70,H2-KE6 |
| Steroid biosynthesis | FDFT1,EBP,CYP51,MSMO1,SQLEA,DHCR24,CELL,DHCR7,CYP2R1,CPN1 |
Protein Function
HSD17B7 has several biochemical functions, for example, 3-keto sterol reductase activity,estradiol 17-beta-dehydrogenase activity,prolactin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD17B7 itself. We selected most functions HSD17B7 had, and list some proteins which have the same functions with HSD17B7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| prolactin receptor binding | GH1,PRL4A1,PRL |
| estradiol 17-beta-dehydrogenase activity | HSD17B14,RDH8B,HSD17B11,HSD17B12B,RDH8,HSD17B12A,HSD17B2,RDH8A,AKR1C6,HSD17B1 |
| 3-keto sterol reductase activity | DHRS4,CBR3 |
Interacting Protein
HSD17B7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD17B7 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD17B7.
CA1;DTYMK;GORAB;AGPAT6;BRSK1
Resources
Related Services
Related Products
References
- Seth, G; Ozturk, M; et al. Reverting cholesterol auxotrophy of NS0 cells by altering epigenetic gene silencing. BIOTECHNOLOGY AND BIOENGINEERING 93:820-827(2006).
