HSD17B4
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Official Full Name
hydroxysteroid (17-beta) dehydrogenase 4 -
Overview
The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. -
Synonyms
HSD17B4;hydroxysteroid (17-beta) dehydrogenase 4;peroxisomal multifunctional enzyme type 2;3 alpha;7 alpha;12 alpha trihydroxy 5 beta cholest 24 enoyl CoA hydratase;17 beta HSD IV;17 beta hydroxysteroid dehydrogenase 4;17beta estradiol dehydrogena
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- HEK293T
- Yeast
- Mammalian cells
- In Vitro Cell Free System
- GST
- His
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
Involved Pathway
HSD17B4 involved in several pathways and played different roles in them. We selected most pathways HSD17B4 participated on our site, such as Primary bile acid biosynthesis,Metabolic pathways,Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD17B4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peroxisome | PRDX5,HMGCLL1,PHYH,ACOX1,ABCD2,PXMP4,PEX6,PEX11G,ACSL1B,CRATB |
| Primary bile acid biosynthesis | BAAT,SCP2,CYP46A1.3,CYP46A1.4,CH25HL2,CYP7B1,HSD3B7,ACOX2,SCP2A,AMACR |
| Metabolic pathways | NAGK,CYP2J2,OGDH,GANAB,ASAH2,ADH1,PGAM1A,B3GNT3,MGAT1A,NME4 |
Protein Function
HSD17B4 has several biochemical functions, for example, 17-beta-hydroxysteroid dehydrogenase (NAD+) activity,3-hydroxyacyl-CoA dehydrogenase activity,3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD17B4 itself. We selected most functions HSD17B4 had, and list some proteins which have the same functions with HSD17B4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| isomerase activity | PPIAB,PGAM1,HMGCS1,PDIP5,TPI1B,ITPK1A,PGAM1A,PPIFA,PBLD2,PDIA5 |
| long-chain-enoyl-CoA hydratase activity | HADHA |
| 3-hydroxyacyl-CoA dehydrogenase activity | HSD17B8,H2-KE6,HADH,HADHB,HADHAB,HSD17B10,HADHAA,EHHADH,HADHA |
| receptor binding | TRIM24,WNT7AA,FGF6A,NUDT19,AMH,SELPLG,AMACR,HAMP,TNFSF14,F2R |
| protein homodimerization activity | GIMAP7,SH3GLB1,ATPIF1B,LRRC41,CLIC6,BOK,FBXO4,PRDX4,KIF20B,RPE |
Interacting Protein
HSD17B4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD17B4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD17B4.
PLEK;GSK3B;RELB;NDRG1;UBA5;MAPK8;CDK7;CASP9;BAK1;q74yg8_yerpe;midostaurin;ssrna_ag
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