HSD17B11
-
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 11 -
Overview
Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001;(PubMed 11165019)). -
Synonyms
HSD17B11;hydroxysteroid (17-beta) dehydrogenase 11;dehydrogenase/reductase (SDR family) member 8 , DHRS8;estradiol 17-beta-dehydrogenase 11;17 BETA HSD11;17 BETA HSDXI;PAN1B;retinal short chain dehydrogenase/reductase 2;RetSDR2;SDR16C2;short cha
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- His&Myc
- His&SUMO
- Flag
Involved Pathway
HSD17B11 involved in several pathways and played different roles in them. We selected most pathways HSD17B11 participated on our site, such as Estrogen biosynthesis,Metabolism,Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD17B11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Estrogen biosynthesis | AKR1B15,CYP19A1 |
| Metabolism of steroid hormones and vitamin D | STARD5,CYP27B1,AKR1B15,CYP24A1,CYP2R1,PPP1R2,GC |
| Metabolism | SLC5A6B,CYP2K8,CYP17A1,PCBD1,TIAM2,ATP5L,CKMB,PFKLB,CIAO1,NEU4 |
| Metabolism of lipids and lipoproteins | FAAH2B,MED8,CYP4B1,GPAT2,FABP12,NFYBB,AKR1C21,CYP2AD6,FABP11B,PTPMT1 |
Protein Function
HSD17B11 has several biochemical functions, for example, estradiol 17-beta-dehydrogenase activity,steroid dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD17B11 itself. We selected most functions HSD17B11 had, and list some proteins which have the same functions with HSD17B11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| steroid dehydrogenase activity | SDR42E1,HSD11B1LA,HSD3B6,AKR1C21,HSD3B5,SDR16C6,H2-KE6,AKR1C6 |
| estradiol 17-beta-dehydrogenase activity | HSD17B10,HSD17B12B,RDH8A,HSD17B6,RDH8B,H2-KE6,HSD17B2,AKR1B15,RDH8,HSD17B7 |
Interacting Protein
HSD17B11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD17B11 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD17B11.
PTP4A3;BRF2;GSTK1
Resources
Related Services
Related Products
References
- Legeza, B; Balazs, Z; et al. The Microsomal Enzyme 17 beta-Hydroxysteroid Dehydrogenase 3 Faces the Cytoplasm and Uses NADPH Generated by Glucose-6-Phosphate Dehydrogenase. ENDOCRINOLOGY 154:205-213(2013).
- Patel, K; Farlow, EC; et al. Enhancement of a multianalyte serum biomarker panel to identify lymph node metastases in non-small cell lung cancer with circulating autoantibody biomarkers. INTERNATIONAL JOURNAL OF CANCER 129:133-142(2011).
