HOXC6
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Official Full Name
homeobox C6 -
Overview
This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5 non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq, Jul 2008] -
Synonyms
HOXC6;homeobox C6;CP25;HOX3;HOX3C;HHO.C8;homeobox protein Hox-C6;homeo box 3C;homeo box C6;homeo box C8 protein;homeobox protein CP25;homeobox protein HHO.C8;homeobox protein Hox-3C
Recombinant Proteins
- Human
- Mouse
- E.coli
- E. coli
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- N-His
- HIS
- Non
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HOXC6-13907H | Recombinant Human HOXC6, GST-tagged | E.coli | Human | GST | 1-120a.a. | |
| ADH1B-9417H | Recombinant Human ADH1B protein, His-tagged | E. coli | Human | N-His | 1-375 aa | |
| HOXC6-094H | Recombinant Human HOXC6 Protein, HIS-tagged | E.coli | Human | HIS |
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| HOXC6-29377TH | Recombinant Human HOXC6 | Wheat Germ | Human | Non | 235 amino acids |
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| HOXC6-29380TH | Recombinant Human HOXC6 | Wheat Germ | Human | Non | 90 amino acids |
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| HOXC6-4983H | Recombinant Human HOXC6 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HOXC6-5415HCL | Recombinant Human HOXC6 293 Cell Lysate | HEK293 | Human | Non |
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| HOXC6-5416HCL | Recombinant Human HOXC6 293 Cell Lysate | HEK293 | Human | Non |
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| Hoxc6-1158M | Recombinant Mouse Hoxc6 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| HOXC6-1598H | Recombinant Human HOXC6 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| HOXC6-239HF | Recombinant Full Length Human HOXC6 Protein | In Vitro Cell Free System | Human | Full L. 235 amino acids |
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| HOXC6-3728HF | Recombinant Full Length Human HOXC6 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 235 amino acids |
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Involved Pathway
HOXC6 involved in several pathways and played different roles in them. We selected most pathways HOXC6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HOXC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HOXC6 has several biochemical functions, for example, sequence-specific DNA binding,transcription corepressor activity,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOXC6 itself. We selected most functions HOXC6 had, and list some proteins which have the same functions with HOXC6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | NKX2-3,ENG1B,DLX2A,CDX1B,GATAD2AB,TRP53,NR2F6,NR0B1,IRX5B,NKX2.1 |
| transcription factor activity, sequence-specific DNA binding | CITED1,STAT4,GRHL2,RCOR2,ZNF165,HIST1H2AH,ZNF157,ZNF711,RXRGA,FOXL2 |
| transcription corepressor activity | SMARCA4,SSX4,HDAC7,UBP1,SFMBT1,ZHX2,E2F8,SSX1,SKIL,PPP1R13L |
Interacting Protein
HOXC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HOXC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of HOXC6.
BCAR3;CHEK2;TGFB1;IGF1R;FGFR2;APC;PTPRJ
Resources
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References
- Wang, DD; Xu, Y; et al. Comparison Analysis in Synchronous and Metachronous Metastatic Colorectal Cancer Based on Microarray Expression Profile. HEPATO-GASTROENTEROLOGY 61:2215-2218(2014).
- Paziewska, A; Dabrowska, M; et al. DNA methylation status is more reliable than gene expression at detecting cancer in prostate biopsy. BRITISH JOURNAL OF CANCER 111:781-789(2014).
