HOXA9
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Official Full Name
homeobox A9 -
Overview
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene. -
Synonyms
HOXA9;homeobox A9;homeo box A9 , HOX1, HOX1G;homeobox protein Hox-A9;ABD-B;Abd-B, drosophila, homolog of;D6a9;Homeobox 1G;Homeobox protein Hox-1.7;Homeobox protein Hox-1G;Hox-1.7;Hox-1.7, mouse, homolog of;HOX1;Hox1.7;Hox1G;Hox1r5;Hoxa-9;Hoxa7;HOXA9/MSI2 fusion gene, included;HOXA9/NUP98 fusion gene, included;MGC1934;OTTHUMP00000217260;homeodomain protein HOXA9
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- His&T7
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
HOXA9 involved in several pathways and played different roles in them. We selected most pathways HOXA9 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with HOXA9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | PDGFA,RELA,SIX1,PPARG,Bcl2a1b,IL3,KDM6A,IL1R2,BCL2A1,ETV5 |
Protein Function
HOXA9 has several biochemical functions, for example, enzyme binding,protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOXA9 itself. We selected most functions HOXA9 had, and list some proteins which have the same functions with HOXA9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | NOXO1,SNX12,PTPN1,YES1,USP22,RPA3,CYP2E1,CYP2A6,PARP1,HSPA5 |
| sequence-specific DNA binding | DLX3B,HOXA9B,HOXC1A,PRDM5,MAFK,FOXF2A,CREB3L1,ELF2B,NKX3.2,CTCFL |
| protein binding | MYBPC2,RXFP1,RNF43,ALKBH6,RPS27A,ORM1,PPP4C,CNOT3,S100A11,NAA35 |
Interacting Protein
HOXA9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HOXA9 here. Most of them are supplied by our site. Hope this information will be useful for your research of HOXA9.
TRIP6;HDAC1;SUZ12;PLSCR1;RBPMS;PTBP3
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