HOXA10
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Official Full Name
homeobox A10 -
Overview
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011] -
Synonyms
HOXA10;homeobox A10;PL;HOX1;HOX1H;HOX1.8;homeobox protein Hox-A10;homeo box A10;homeobox protein 1H;homeobox protein HOXA10;homeobox protein Hox-1H;homeobox protein Hox-1.8
Recombinant Proteins
- Human
- Mouse
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HOXA10-4939H | Recombinant Human HOXA10 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HOXA10-7785M | Recombinant Mouse HOXA10 Protein | Mammalian Cell | Mouse | His |
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| HOXA10-5429HCL | Recombinant Human HOXA10 293 Cell Lysate | HEK293 | Human | Non |
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| Hoxa10-1152M | Recombinant Mouse Hoxa10 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| HOXA10-3707HF | Recombinant Full Length Human HOXA10 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 393 amino acids |
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| HOXA10-4275M | Recombinant Mouse HOXA10 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| HOXA10-4275M-B | Recombinant Mouse HOXA10 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| HOXA10-5973H | Recombinant Human HOXA10 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
HOXA10 involved in several pathways and played different roles in them. We selected most pathways HOXA10 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with HOXA10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | SUPT3H,MLLT1,BIRC3,IL1R2,WT1,ITGB7,ETV7,TRAF1,GOLPH3,LRP2BP |
Protein Function
HOXA10 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,histone deacetylase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOXA10 itself. We selected most functions HOXA10 had, and list some proteins which have the same functions with HOXA10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | FIGLA,BARHL2,ZNF750,MITFA,HOXC11,GRHL1,NR1H4,RBPJ,PATZ1,KLF15 |
| protein binding | THBD,CEP72,TBX18,ATP2C2,INPP4B,SERPINB9,SH3YL1,COL23A1,ABI1,PAFAH1B1 |
| histone deacetylase binding | CBX5,FOXP3,HDAC9,NCOR1,HDAC5,TRAF6,CCND1,TFAP4,SIRT2,NCOR2 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NFAT5,BATF,TFE3A,ZNF395,GRHL1,CEBPB,PHOX2B,KLF13,ELK3,EBF1 |
Interacting Protein
HOXA10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HOXA10 here. Most of them are supplied by our site. Hope this information will be useful for your research of HOXA10.
SPI1;MYC;PTPN11
Resources
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References
- Kallen, AN; Haines, K; et al. HOXA10 Regulates Expression of Cytokeratin 15 in Endometrial Epithelial Cytoskeletal Remodeling. REPRODUCTIVE SCIENCES 21:892-897(2014).
- Cui, XP; Qin, CK; et al. HOXA10 Promotes Cell Invasion and MMP-3 Expression Via TGF beta 2-Mediated Activation of the p38 MAPK Pathway in Pancreatic Cancer Cells. DIGESTIVE DISEASES AND SCIENCES 59:1442-1451(2014).
