HNRNPH1
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Official Full Name
heterogeneous nuclear ribonucleoprotein H1 (H) -
Overview
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. It is very similar to the family member HNRPF. This gene is thought to be potentially involved in hereditary lymphedema type I phenotype. -
Synonyms
HNRNPH1;heterogeneous nuclear ribonucleoprotein H1 (H);HNRPH1;heterogeneous nuclear ribonucleoprotein H;hnRNPH;DKFZp686A15170;Heterogeneous nuclear ribonucleoprotein H1;HNRPH 1;HNRPH;HNRPH1 protein;hnRNP H
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- Rat
- E.coli
- HEK293
- Mammalian Cell
- Mammalian cells
- His
- His&SUMO
- Non
- His&Fc&Avi
- GST
- Flag
Involved Pathway
HNRNPH1 involved in several pathways and played different roles in them. We selected most pathways HNRNPH1 participated on our site, such as Gene Expression,Processing of Capped Intron-Containing Pre-mRNA,mRNA Splicing, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNRNPH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA processing | PTBP1,LSMD1,EBI3,SF3A1,SRPK2,Akap17b,SFRS3A,LOC100862398,ADAM5,SF3B4 |
| mRNA Splicing - Major Pathway | HNRPL,CD2BP2,PTBP1,BCAS2,DNAJC8,SF3A1,PTBP1A,HNRNPH2,HNRNPA0,PRPF8 |
| Processing of Capped Intron-Containing Pre-mRNA | RNPC3,METTL3,HNRNPH2,PTBP1,CSTF2,YBX1,SF3A1,HNRNPR,HNRNPUL1,TTC6 |
| mRNA Splicing | CCAR1,HNRNPA0B,HNRNPL,PRPF8,PDCD7,HNRPL,HNRNPH1L,HNRNPR,ZMAT5,SF3B4 |
| Gene Expression | NRBF2B,ZNF729,ZNF398,ZFP2,HNRNPA0L,GTF3C3,AIMP1,KARS,ZKSCAN4,ADAT1 |
Protein Function
HNRNPH1 has several biochemical functions, for example, RNA binding,nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNRNPH1 itself. We selected most functions HNRNPH1 had, and list some proteins which have the same functions with HNRNPH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(U) RNA binding | DIS3L2,KHDRBS2,PABPC4,PATL2,HNRNPC,PNPT1,PABPC1,KHDC1A,MSI1,PATL1 |
| RNA binding | Akap17b,ATXN1L,SURF6,RBMS2,SAMHD1,C1D,XPO1,DDX19A,PPIE,TLR13 |
| protein binding | OAZ1,PDPK1,NISCH,MCM8,MATN3,PSMB10,SETMAR,BSX,BMP4,MZT1 |
| poly(A) RNA binding | ZNF326,KHSRP,SSBP1,NAT10,CDK11B,SPATS2L,RPL3,DDX5,LAS1L,CALR |
| nucleotide binding | JAK2B,PPIP5K2,GC2,LARP7,HSP90AA1,RPS6KB1B,MSI2,TLK1A,NTRK2B,RERGLA |
Interacting Protein
HNRNPH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNRNPH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HNRNPH1.
EGFR;HNRNPA1;NFKB2;Hnrnph1;ZWINT;ACTB;YWHAG;Cbx1;REL;IKBKE;NDRG1;CELF1;MAP3K3;MBNL1;TAB2;RIPK3;TOM1L1;DDX5
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References
- Miyaso, H; Nakamura, N; et al. Early Postnatal Exposure to a Low Dose of Decabromodiphenyl Ether Affects Expression of Androgen and Thyroid Hormone Receptor-Alpha and Its Splicing Variants in Mouse Sertoli Cells. PLOS ONE 9:-(2014).
- Nishida, Y; Aida, K; et al. Antibody-Validated Proteins in Inflamed Islets of Fulminant Type 1 Diabetes Profiled by Laser-Capture Microdissection Followed by Mass Spectrometry. PLOS ONE 9:-(2014).
