HNF1B
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Official Full Name
HNF1 homeobox B -
Overview
This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
HNF1B;HNF1 homeobox B;TCF2, transcription factor 2, hepatic;LF B3;variant hepatic nuclear factor;hepatocyte nuclear factor 1-beta;HNF1beta;LFB3;MODY5;VHNF1;TCF-2;HNF-1B;HNF-1-beta;HNF1 beta A;homeoprotein LFB3;transcription factor 2, hepat
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
HNF1B involved in several pathways and played different roles in them. We selected most pathways HNF1B participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNF1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Maturity onset diabetes of the young | HHEX,NEUROD1,INS2,MAFA,NKX6-1,HNF1A,SLC2A2,FOXA3,BHLHA15,IAPP |
Protein Function
HNF1B has several biochemical functions, for example, DNA binding,core promoter proximal region DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNF1B itself. We selected most functions HNF1B had, and list some proteins which have the same functions with HNF1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | CSRNP3,ZBTB49,NR2F6,RAX2,FOXJ2,CREB3L3A,MSXA,FOXG1A,NANOGP8,ETV5B |
| protein homodimerization activity | ABP1,PRDX4,BHLHB9,GSTZ1,CHMP4C,BMP7A,PEX11A,SHMT1,EIF2AK3,NTRK1 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | GATA5,FOXF2A,THRA,CEBPB,MYOG,NKX2-1,FOXP3,PURA,NKX2-5,NR1H4 |
| DNA binding | ZNF446,C19orf40,MEIS1B,FOXQ2,TAF15,HOXC4A,DMTF1,DLX4A,HMGB4,LCORL |
| protein complex binding | ST13,CAPG,STRN,NOG,RIPK1,DRD1A,WASF2,YWHAB,LRP2,MTHFR |
| transcription factor activity, sequence-specific DNA binding | MAFG,ZNF621,SOX4,BTBD8,MECOM,MECP2,ZNF383,BHLHE22,NR5A2,FOXO6 |
| protein binding | FBXO18,CTNNA2,NUAK2,BAZ2A,PPP1CC,SEPT7,ITGA6,SMIM3,CT45A3,ILF3 |
| protein heterodimerization activity | NFKB1,TGFB1,DRAP1,RBP4,BDKRB2,PRSS28,HOMER1,ATF2,LIFR,HIST1H2BA |
Interacting Protein
HNF1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNF1B here. Most of them are supplied by our site. Hope this information will be useful for your research of HNF1B.
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Resources
Research Area
Hepatic Progenitor Cell Transcription FactorsEarly Endodermal Lineage Markers
Hepatic and Pancreatic Progenitor Cell Transcription Factors
Endodermal Lineage Markers
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References
