HMMR
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Official Full Name
hyaluronan-mediated motility receptor (RHAMM) -
Overview
The CD168 antigen is a non-integral cell surface hyaluronan receptor and intracellular protein. When hyaluronan binds to CD168, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. CD168 activation regulates various cellular processes including cell migration, proliferation, signaling, regulation of gene expression, cell differentiation, morphogenesis, and metastasis via both extracellular and intracellular pathways. CD168 is involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. CD168 is also a subunit of the HARC complex. CD168 knockdown in human embryonic stem cells results in downregulation of several pluripotency markers, induction of early extraembryonic lineages, loss of cell viability, and changes in cell cycle. -
Synonyms
HMMR;hyaluronan-mediated motility receptor (RHAMM);hyaluronan mediated motility receptor;CD168;RHAMM;receptor for hyaluronan-mediated motility;intracellular hyaluronic acid-binding protein;IHABP;MGC119494;MGC119495
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
HMMR involved in several pathways and played different roles in them. We selected most pathways HMMR participated on our site, such as ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMMR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ECM-receptor interaction | ITGA2B,COL5A1,VTNA,IBSP,FN1,ITGAV,LAMB4,COL4A4,ITGA11A,THBS1 |
Protein Function
HMMR has several biochemical functions, for example, hyaluronic acid binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HMMR itself. We selected most functions HMMR had, and list some proteins which have the same functions with HMMR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FLII,DEDD,HIF1AN,GOLPH3,RINL,CRABP2,Il4ra,BCAR3,C19orf40,TMEM173 |
| hyaluronic acid binding | TNFAIP6,VCANB,VCAN,C1QBP,IMPG2,HAPLN1,HAPLN4,HAPLN1A,STAB2,HYAL2 |
Interacting Protein
HMMR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMMR here. Most of them are supplied by our site. Hope this information will be useful for your research of HMMR.
MORN4;Dynll1;Bach1;Ndc80;NAT2;CDH13;IL24;GREB1;ITIH5;THRSP;PTBP3;CSNK1A1;CSNK1E;Fam83d;TBK1
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