HMGCL
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Official Full Name
3-hydroxymethyl-3-methylglutaryl-CoA lyase
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- Insect Cell
- In Vitro Cell Free System
- His
- GST
- His&T7
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
HMGCL involved in several pathways and played different roles in them. We selected most pathways HMGCL participated on our site, such as Synthesis and degradation of ketone bodies,Valine, leucine and isoleucine degradation,Butanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGCL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peroxisome | ACOX3,CRATB,BAAT,PEX14,NOS2B,IDH2,SOD2,NUDT19,PHYH,PEX11C |
| Butanoate metabolism | OXCT2A,HADHA,L2HGDH,OXCT1,ECHS1,ACAT1,ACADS,GAD2,HADHAA,ACAT2 |
| Synthesis and degradation of ketone bodies | OXCT2B,HMGCS1,OXCT2,HMGCS2,ACAT2,HMGCLL1,OXCT1A,ACAT1,BDH1,OXCT1 |
| Valine, leucine and isoleucine degradation | ALDH9A1,MCCC2,AOX2P,HADHB,ALDH1B1,HADHAA,MUT,HMGCS2,HMGCS1,BCKDHB |
| Metabolic pathways | AK1,PIP5K1B,AKR1B8,EPHX2,COX7C,NADK2,FLAD1,SMPD3,ME1,CAD |
Protein Function
HMGCL has several biochemical functions, for example, carboxylic acid binding,fatty-acyl-CoA binding,hydroxymethylglutaryl-CoA lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGCL itself. We selected most functions HMGCL had, and list some proteins which have the same functions with HMGCL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| magnesium ion binding | SERPINB1A,NUDT16,RPS6KA3B,TSSK6,PRPS1B,TREX2,SPHK1,STK4,PPA2,ADPRHL1 |
| metal ion binding | RXRGB,CPSF3,SMAD5,PGM2L1,ATP1A1A.2,ZNF317,LHX1A,KDM6BB,GALNT11,PDE4B |
| manganese ion binding | GLUL,XPNPEP3,ME1,WRN,NPEPL1,XPNPEP1,DYRK2,PPM1BA,MTPAP,GALNT1 |
| receptor binding | PECR,MAP7,CADM2A,ANG,CHRNA10,HLA-G,FGF1A,PANX1,PAOX,CLCF1 |
| carboxylic acid binding | AKR1C2,HIF1AN,AKR1C21,PCK1,GRHPR,GOT1 |
| hydroxymethylglutaryl-CoA lyase activity | HMGCLL1 |
| protein homodimerization activity | MYOM3,GABRR1,ANXA1,ZFP652,MLL1,MYPOP,FIGF,MTPAP,DMRTA1,CBLN1 |
| fatty-acyl-CoA binding | ACAD9,ACADS,ECI2,SOAT1,ACBD5,ACBD5A,ACADSB,PECI,ACBD5B,ACOX1 |
Interacting Protein
HMGCL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGCL here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGCL.
DNAJA1;GTF2B;HES1;ARL6IP1;q5ngc7_fratt;RNF126;MS4A7;ADAMTS10;SIRT4
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