HMGB3
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Official Full Name
high mobility group box 3 -
Overview
HMGB3 belongs to the high mobility group (HMG) protein superfamily. Like HMG1 (MIM 163905) and HMG2 (MIM 163906), HMGB3;contains DNA-binding HMG box domains and is classified into the HMG box subfamily. Members of the HMG box subfamily;are thought to play a fundamental role in DNA replication, nucleosome assembly and transcription (Wilke et al., 1997;(PubMed 9370291); Nemeth et al., 2006 (PubMed 16945912)). -
Synonyms
HMGB3;high mobility group box 3;high mobility group (nonhistone chromosomal) protein 4 , high mobility group box 3 , HMG4;high mobility group protein B3;HMG2A;MGC90319;non histone chromosomal protein;High mobility group protein 2a;High mobility group protein HMG4;HMG 4;HMGB 3;Nonhistone chromosomal protein HMG4;high-mobility group box 3;high mobility group protein 4;non-histone chromosomal protein;high-mobility group (nonhistone chromosomal) protein 4;HMG4;HMG-4;HMG-2a
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- E.coli
- HEK293
- Wheat Germ
- Mammalian Cell
- Mammalian cells
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HMGB3-3010H | Recombinant Human HMGB3 protein, His-tagged | E.coli | Human | His | 1-103 aa | |
| HMGB3-105H | Recombinant Human HMGB3, His-tagged | HEK293 | Human | His | 2-200 a.a. |
|
| HMGB3-15882H | Recombinant Human HMGB3, His-tagged | E.coli | Human | His | 1-180aa |
|
| HMGB3-4872H | Recombinant Human HMGB3 Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| HMGB3-6847C | Recombinant Chicken HMGB3 | Mammalian Cell | Chicken | His |
|
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| HMGB3-7730M | Recombinant Mouse HMGB3 Protein | Mammalian Cell | Mouse | His |
|
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| HMGB3-801HCL | Recombinant Human HMGB3 cell lysate | Human | Non |
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| Hmgb3-1627R | Recombinant Rat Hmgb3 Protein, His-tagged | E.coli | Rat | His | Ser14-Ala176 |
|
| HMGB3-301335H | Recombinant Human HMGB3 protein, GST-tagged | E.coli | Human | GST | Met1-Phe103 |
|
| HMGB3-3355H | Recombinant Human HMGB3 Protein (Met1-Glu200), C-His tagged | Mammalian cells | Human | His | Met1-Glu200 |
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| HMGB3-3356H | Recombinant Human HMGB3 Protein (Ser14-Ala176), N-His tagged | E.coli | Human | His | Ser14-Ala176 |
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| HMGB3-3645HF | Recombinant Full Length Human HMGB3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 200 amino acids |
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| HMGB3-4238M | Recombinant Mouse HMGB3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| HMGB3-4238M-B | Recombinant Mouse HMGB3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
HMGB3 involved in several pathways and played different roles in them. We selected most pathways HMGB3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HMGB3 has several biochemical functions, for example, DNA binding, bending,chromatin binding,double-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGB3 itself. We selected most functions HMGB3 had, and list some proteins which have the same functions with HMGB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| double-stranded DNA binding | NTHL1,MTERFD2,KLF6,TARDBP,TP73,GATA1A,ERCC5,RAD51B,TEF,TDP1 |
| DNA binding, bending | LEF1,TOP2A,HMGB2,TFAM,FOXD4,CRIP1,FOXL1,FOXD1,HHEX,HMGB1 |
| chromatin binding | POLE,GATA6,RAN,SAFB,HDAC5,CAPNS2,SP140,SIN3B,ENY2,SIX1 |
| protein binding | RPS6KA1,H2-AB1,ZBTB9,GTF2H2,DEDD,RNF182,GPN1,SPRED1,GIMAP5,KRT14 |
| four-way junction DNA binding | HMGB1,RAD51L3,MEN1,RAD51L1,RAD51,YY1,DMC1,HMGB2 |
| poly(A) RNA binding | UBA1,TNPO1,MRPL37,MFAP1B,D19BWG1357E,KPNB1,NGRN,SRP54B,DBR1,SBDS |
Interacting Protein
HMGB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGB3.
SDCBP;TERF2IP;mdm2_human_probe
Resources
Research Area
Hematopoietic Stem Cell Transcription Factors and RegulatorsHematopoietic Progenitor Cell Markers
Related Services
Related Products
References
- Kim, HY; Park, SY; et al. Inhibition of HMGB1-Induced Angiogenesis by Cilostazol via SIRT1 Activation in Synovial Fibroblasts from Rheumatoid Arthritis. PLOS ONE 9:-(2014).
- de Souza, AWS; Abdulahad, WH; et al. Are urinary levels of high mobility group box 1 markers of active nephritis in anti-neutrophil cytoplasmic antibody-associated vasculitis?. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:270-278(2014).
