HMBS
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Official Full Name
hydroxymethylbilane synthase -
Overview
This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described. Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. -
Synonyms
HMBS;hydroxymethylbilane synthase;PBGD, PORC, porphobilinogen deaminase , porphyria, acute;Chester type , UPS, uroporphyrinogen I synthase;porphobilinogen deaminase;HEM3_HUMAN;PBG D;PBG-D;PBGD;Pre uroporphyrinogen synthase;Pre-uroporphyrinogen synthase;UPS;Uroporphyrinogen I synthase;Uroporphyrinogen I synthetase;OTTHUMP00000238530;OTTHUMP00000238532;OTTHUMP00000238533;OTTHUMP00000238534;OTTHUMP00000238537;OTTHUMP00000238539;OTTHUMP00000238540;OTTHUMP00000238541;OTTHUMP00000238580;PORC;EC 2.5.1.61
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
HMBS involved in several pathways and played different roles in them. We selected most pathways HMBS participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HMBS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
HMBS has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by HMBS itself. We selected most functions HMBS had, and list some proteins which have the same functions with HMBS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
HMBS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMBS here. Most of them are supplied by our site. Hope this information will be useful for your research of HMBS.
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