HM13
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Official Full Name
histocompatibility (minor) 13 -
Overview
The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. -
Synonyms
HM13;histocompatibility (minor) 13;minor histocompatibility antigen H13;dJ324O17.1;H13;IMP1;IMPAS;intramembrane protease;presenilin like protein 3;PSENL3;PSL3;signal peptide peptidase beta;signal peptide peptidase like 1;SPP;SPPL1;IMP-1;hI
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Human
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HM13-11852Z | Recombinant Zebrafish HM13 | Mammalian Cell | Zebrafish | His |
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| HM13-2104R | Recombinant Rhesus monkey HM13 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| HM13-4855H | Recombinant Human HM13 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HM13-5486HCL | Recombinant Human HM13 293 Cell Lysate | HEK293 | Human | Non |
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| HM13-5487HCL | Recombinant Human HM13 293 Cell Lysate | HEK293 | Human | Non |
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| HM13-1925R | Recombinant Rhesus Macaque HM13 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| HM13-1925R-B | Recombinant Rhesus Macaque HM13 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| HM13-21H | Recombinant Human HM13 protein, His-tagged | E.coli | Human | His | 111-220 aa |
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| HM13-3635HF | Recombinant Full Length Human HM13 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 143 amino acids |
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Involved Pathway
HM13 involved in several pathways and played different roles in them. We selected most pathways HM13 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HM13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HM13 has several biochemical functions, for example, aspartic endopeptidase activity, intramembrane cleaving,peptidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HM13 itself. We selected most functions HM13 had, and list some proteins which have the same functions with HM13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | PCBP2,PIAS2,HSPA8,FZD8,HSPA5,RNF20,HSPA9,RRAGA,TOLLIP,TRAF1 |
| peptidase activity | lon,PRSS59.1,TMPRSS4A,CASP3A,USPL1,C6AST4,KLK1B9,GM12824,ELA2,ADAMTS16 |
| protein homodimerization activity | TGFB2,WHRN,MCL1,KIAA1804,SRGAP2,DGCR8,PPP2R4,ABCD1,OXA1L,GOLGA5 |
| protein binding | JUP,RHNO1,B2M,POU2F3,RPA2,KIAA0247,TSC22D3,STX12,AKAP6,CD93 |
| aspartic endopeptidase activity, intramembrane cleaving | SPPL3,SPPL2B |
Interacting Protein
HM13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HM13 here. Most of them are supplied by our site. Hope this information will be useful for your research of HM13.
LZTS2;XBP1;RNF139;DERL1;env;P4HB;ABHD16A;q9wmx2-pro_0000037541
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