HLTF
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Official Full Name
helicase-like transcription factor -
Overview
This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq, Jul 2008] -
Synonyms
HLTF;helicase-like transcription factor;ZBU1;HLTF1;RNF80;HIP116;SNF2L3;HIP116A;SMARCA3;SNF2-like 3;RING finger protein 80;sucrose nonfermenting-like 3;sucrose nonfermenting protein 2-like 3;DNA-binding protein/plasminogen activator inhibitor 1 regulator;DNA-binding protein/plasminogen activator inhibitor-1 regulator;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3;SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3
Recombinant Proteins
- Mouse
- Human
- Mammalian Cell
- E.coli
- HEK293
- His
- His&T7
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLTF-7718M | Recombinant Mouse HLTF Protein | Mammalian Cell | Mouse | His |
|
|
| HLTF-7859H | Recombinant Human HLTF protein, His & T7-tagged | E.coli | Human | His&T7 | Ala837~Lys996 |
|
| Hltf-7860M | Recombinant Mouse Hltf protein, His & T7-tagged | E.coli | Mouse | His&T7 | Ala831~Lys990 |
|
| HLTF-5489HCL | Recombinant Human HLTF 293 Cell Lysate | HEK293 | Human | Non |
|
|
| HLTF-0511H | Recombinant Human HLTF Protein (V58-A174), Tag Free | E.coli | Human | Non | V58-A174 |
|
| HLTF-0512H | Recombinant Human HLTF Protein (V58-A174), His tagged | E.coli | Human | His | V58-A174 |
|
| HLTF-3179H | Recombinant Human HLTF Protein (Ala837-Lys996), N-His tagged | E.coli | Human | His | Ala837-Lys996 |
|
| HLTF-4231M | Recombinant Mouse HLTF Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
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| HLTF-4231M-B | Recombinant Mouse HLTF Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
HLTF involved in several pathways and played different roles in them. We selected most pathways HLTF participated on our site, such as RB in Cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLTF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RB in Cancer | HMGB2,DCK,FAF1,PRMT2,ANLN,RBP1,RABIF,TOP2A,SMARCA2 |
Protein Function
HLTF has several biochemical functions, for example, ATP binding,ATPase activity,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLTF itself. We selected most functions HLTF had, and list some proteins which have the same functions with HLTF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | FOXJ1,HINFP,POU1F1,ZSCAN21,TCF4,AGO1,E2F4,JUN,NFIB,MYPOP |
| ubiquitin protein ligase activity | C12orf51,RNF6,HECW2,MED1,HERC6,UBR3,TMEM189,CDK8,ITCH,UBE2G2 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | POU4F2,CEBPG,NKX2-8,NOBOX,MZF1,MEF2A,IRF4,NR1H4,ELF3,MESP1 |
| protein binding | SALL4,SLAMF1,IPO4,ANXA9,GH1,DPCD,PRR13,TMEM41A,PXN,TSSC4 |
| ATPase activity | ABCA6,KIF4,ATP13A3,KIF14,EIF4A1B,ABCF2A,MYO19,ABCC12,ATAD2,NSFB |
| ligase activity | RNF212,ZNRF1,UBE3B,RNF34,DZIP3,TRIM69,RNF19B,RNF169,UBE2D1B,TRIM9 |
| helicase activity | SMARCA5,DHX37,SMARCA4,DNA2,WRN,DDX19B,DDX3,EIF4A1A,DHX34,DQX1 |
| poly(A) RNA binding | IPO5,HIST1H4A,EEF1A1,SF3A2,PARP12,PPIA,RBM15,SRP72,SARS2,DDX50 |
| zinc ion binding | FTR82,ING2,NANOS1,MT1F,COP1,XAF1,ENPEP,RNF180,MAN2B2,RNF139 |
Interacting Protein
HLTF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLTF here. Most of them are supplied by our site. Hope this information will be useful for your research of HLTF.
b-box_pai1_3-5prime;S100A10;WBP4;CIAO1;USP7;BRF2;PHLDA3;SULT1C2;HSPA8;CDK9;UBE2Z;s10aa_chlae_protein;E2F3;PTBP3;S100a10
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References
- Helmer, RA; Dertien, JS; et al. Prolactin induces Jak2 phosphorylation of RUSHY195. MOLECULAR AND CELLULAR ENDOCRINOLOGY 338:79-83(2011).
- Krijger, PHL; Lee, KY; et al. HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: Existence of an alternative E3 ligase. DNA REPAIR 10:438-444(2011).
