HLA-DRB4
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Official Full Name
major histocompatibility complex, class II, DR beta 4 -
Overview
HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. -
Synonyms
HLA-DRB4;major histocompatibility complex, class II, DR beta 4;HLA DR4B;DR4;DR-4;leukocyte antigen;MHC class2 antigen;MHC HLA DR-beta chain;MHC class II antigen DRB4;DRB1 transplantation antigen;human leucocyte antigen DRB4;MHC class II antigen
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-DRB4-3738H | Recombinant Human HLA-DRB4 protein, GST-tagged | E.coli | Human | GST | 1-266 aa | |
| HLA-DRB4-1209H | Recombinant Human HLA-DRB4, GST-tagged | Wheat Germ | Human | GST | 30-266 a.a. |
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| HLA-DRB4-5492HCL | Recombinant Human HLA 293 Cell Lysate | HEK293 | Human | Non |
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| HLA-DRB4-2263H | Recombinant Human HLA-DRB4 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| HLA-DRB4-235HF | Recombinant Full Length Human HLA-DRB4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 30 a.a. - 266 a.a. |
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Involved Pathway
HLA-DRB4 involved in several pathways and played different roles in them. We selected most pathways HLA-DRB4 participated on our site, such as Phagosome,Cell adhesion molecules (CAMs),Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DRB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ne network for IgA production | CD40LG,CD40,MHC2A,MHC2DCB,HLA-DPB1,CCL25,CD80,IL15,BMA2,HLA-DOB |
| Autoi | IFNA5,TSHB,HLA-A,TG,CD40LG,IFNA17,IFNA21,HLA-DMB,HLA-C,IFNA14 |
| Inflammatory bowel disease (IBD) | HLA-DRA,GATA3,STAT1,STAT6,H2-AB1,HLA-DMA,IL23R,IFNG,IL18R1,TLR4 |
| Graft-versus-host disease | HLA-DQA2,H2-Q10,HLA-B,Fasl,HLA-DMB,IL1A,HLA-DMA,HLA-DQB1,H2-AB1,FAS |
| Type I diabetes mellitus | INS1,FAS,HLA-E,TNF,HLA-DOB,HLA-DMB,PTPRN2,PRF1,IL12B,HLA-DQB1 |
| Toxoplasmosis | IRAK4,ALOX5,MAPK3,CYCS,PIK3CD,LAMB3,NOS2,XIAP,HSPA8,IL12A |
| Influenza A | DNAJB1,H2-AB1,HSPA1L,Ifna11,IVNS1ABP,Ifna15,IL8L1,TNFRSF10A,MAP2K7,NXT2 |
| Antigen processing and presentation | HLA-DRB5,HLA-DPA1,IFI30,HLA-DPB1,HSPA8,HLA-DQB1,RFXAP,HSP90AA1,PSME2,CALR |
| Phagosome | TAP2,SFTPD,TUBA3C,MARCO,ATP6V1AA,TUBA4A,ITGA5,RAB7,FCGR3B,ATP6V0D2 |
Protein Function
HLA-DRB4 has several biochemical functions, for example, MHC class II receptor activity,peptide antigen binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DRB4 itself. We selected most functions HLA-DRB4 had, and list some proteins which have the same functions with HLA-DRB4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MHC class II receptor activity | HLA-DRB1,HLA-DQA2,HLA-DRB3,HLA-DQA1,HLA-DOB,HLA-DPA1,HLA-DOA,HLA-DRA,HLA-DQB1,KRT17 |
| protein binding | SYT6,ITGB7,GLUD1,EIF4EBP3,GRIN2A,UQCC2,RBMY1F,KPNA6,ZNF276,PIAS3 |
| peptide antigen binding | MHC1ZKA,HLA-B,HLA-DPA1,MR1,CLEC4M,MHC1ZFA,HLA-DRB1,MHC1UKA,TRGV3,CD209 |
Interacting Protein
HLA-DRB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DRB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DRB4.
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References
- Rasmussen, S; Donskov, F; et al. Carbon anhydrase IX specific immune responses in patients with metastatic renal cell carcinoma potentially cured by interleukin-2 based immunotherapy. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 35:487-496(2013).
- Resse, M; Paolillo, R; et al. Anti-HLA-A, -B, -DR,-DQB1 and-DQA1 antibodies reactive epitope determination with HLAMatchmaker in multipare awaiting list for heart transplant. HUMAN IMMUNOLOGY 74:937-941(2013).
