HLA-DPB1

  • Official Full Name

    major histocompatibility complex, class II, DP beta 1
  • Overview

    HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
  • Synonyms

    HLA-DPB1;major histocompatibility complex, class II, DP beta 1;HLA DP1B;HLA class II histocompatibility antigen, DP beta 1 chain;MHC HLA DPB1;HLA DP14-beta chain;MHC class II HLA-DRB1;class II HLA beta chain;MHC class II HLA-DP-beta;MHC class II
Cat.# Product name Source (Host) Species Tag Protein Length Price
HLA-DPB1-30198TH Recombinant Human HLA-DPB1 Wheat Germ Human Non 258 amino acids
HLA-DPB1-4841H Recombinant Human HLA-DPB1 Protein, GST-tagged Wheat Germ Human GST 1-258 a.a.
HLA-DPB1-5505HCL Recombinant Human HLA 293 Cell Lysate HEK293 Human Non
HLA-DPB1-1278H Recombinant Human HLA-DPB1 Protein (30-223 aa), His-tagged E.coli Human His 30-223 aa
HLA-DPB1-231HF Recombinant Full Length Human HLA-DPB1 Protein In Vitro Cell Free System Human Full L. 258 amino acids
HLA-DPB1-3583HF Recombinant Full Length Human HLA-DPB1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 258 amino acids

    Involved Pathway

    HLA-DPB1 involved in several pathways and played different roles in them. We selected most pathways HLA-DPB1 participated on our site, such as Phagosome,Cell adhesion molecules (CAMs),Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DPB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ne thyroid disease IFNA21,HLA-G,IFNA12,HLA-DQA2,GZMB,CD40LG,PRF1,IFNA5,IFNA2,HLA-DRB3
    Toxoplasmosis MAPK9,TGFB1,LAMB3,LAMA5,IL12B,HLA-DQA1,GNAI1,LAMC1,XIAP,HSPA1B
    Graft-versus-host disease HLA-DOA,IL6,TNF,H2-AA,KIR2DL1,KLRC1,HLA-DMA,HLA-DQA1,IFNG,H2-AB1
    ne network for IgA production CCL25B,TNFRSF17,CCR9A,TGFB1,LTBR,HLA-DMB,IL-15RA,TNFRSF13B,ITGB7,ICOS
    Phagosome TUBA8,TUBB6,ATP6V1B1,LAMP2,HLA-G,NCF4,FCGR3,RILP,FCGR1A,C1R
    Intestinal i H2-AB1,CCL25B,CXCL12B,TNFRSF17,IL-15RA,TGFB1,HLA-DQB1,IL5,HLA-DQA2,CD40
    Staphylococcus aureus infection HLA-DOB,ITGB2L,CFH,C1S,FCGR4,C1RA,DSG1A,ITGAL,HLA-DRB1,DSG1
    Epstein-Barr virus infection HLA-F,HDAC1,POLR2C,PSMC3,HLA-DQA1,PSMD3,HLA-B,MAP3K7,POLR2J,ENTPD8
    Systemic lupus erythematosus HIST1H2BP,ACTN1,HLA-DRB5,C1R,HIST1H4F,HIST1H2BI,HIST1H4K,HIST1H2BK,GM14482,C9

    Protein Function

    HLA-DPB1 has several biochemical functions, for example, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DPB1 itself. We selected most functions HLA-DPB1 had, and list some proteins which have the same functions with HLA-DPB1. You can find most of the proteins on our site.

    Function Related Protein
    peptide antigen binding AZGP1,CD209,MHC1UKA,MAML1,MHC1ZFA,TAP1,HLA-B,HLA-DQB1,MHC1ZDA,MHC1UXA2

    Interacting Protein

    HLA-DPB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DPB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DPB1.

    COPB1;recB;manX;pyc;sbcD;hppD;arnA;ROBO2;RTN4

    Resources

    References

    • Lambert, ND; Haralambieva, IH; et al. Polymorphisms in HLA-DPB1 Are Associated With Differences in Rubella Virus-Specific Humoral Immunity After Vaccination. JOURNAL OF INFECTIOUS DISEASES 211:898-905(2015).
    • Baldwin, KM; Ehrenberg, PK; et al. HLA class II diversity in HIV-1 uninfected individuals from the placebo arm of the RV144 Thai vaccine efficacy trial. TISSUE ANTIGENS 85:117-126(2015).

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