HIST3H3
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Official Full Name
histone cluster 3, H3 -
Overview
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in;eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of;each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the;interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.;This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails;;instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that;are in the histone gene cluster on chromosome 6p22-p21.3.
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HIST3H3-290H | Recombinant Human HIST3H3 protein, His-tagged | E.coli | Human | His | 2-137 a.a. |
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| HIST3H3-299H | Recombinant Human HIST3H3 protein, His-tagged | E.coli | Human | His | 2-236 a.a. |
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| HIST3H3-4818H | Recombinant Human HIST3H3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HIST3H3-902H | Recombinant Human HIST3H3 protein | E.coli | Human | Non |
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| HIST3H3-5511HCL | Recombinant Human HIST3H3 293 Cell Lysate | HEK293 | Human | Non |
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| HIST3H3-3606HF | Recombinant Full Length Human HIST3H3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 136 amino acids |
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Involved Pathway
HIST3H3 involved in several pathways and played different roles in them. We selected most pathways HIST3H3 participated on our site, such as Alcoholism,Transcriptional misregulation in cancer,Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIST3H3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Systemic lupus erythematosus | HLA-DMA,HIST2H3A,GM6026,HIST2H2BB,H2AFY2,HIST1H4G,HIST1H4K,HIST1H2AI,SSB,H2AFB1 |
| Alcoholism | HIST1H4I,HIST1H2BG,HIST1H2AP,HIST1H2BH,HIST1H2BJ,HDAC3,DRD1,HIST2H3C2,HIST3H2BB-PS,GNB1 |
| Transcriptional misregulation in cancer | SMAD1,PBX3,SPINT1,LMO2,IGF1,PAX8,HIST1H3F,ZBTB16,MPO,CD14 |
Protein Function
HIST3H3 has several biochemical functions, for example, DNA binding,histone binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HIST3H3 itself. We selected most functions HIST3H3 had, and list some proteins which have the same functions with HIST3H3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | RXRA,H2AFX,HIST1H2BH,HIST1H3F,HIST1H4H,CAPN2,BAX,MLXIPL,TAP1,MEIS1 |
| DNA binding | KAT6B,ZFP276,ZNF410,ZBTB25,ASH1L,RAG2,RYBP,BCLAF1,ZNF444,LMX1BA |
| histone binding | NCL,HIST1H3H,HIST1H3I,NAP1L2,UHRF1,ASF1B,NPM2,PRKCB,HIST1H4J,HIST1H4L |
| protein binding | STX3,OSTF1,YOD1,CDKN2A,FGF12,TDRKH,CYSLTR1,WRN,C5orf13,CD160 |
Interacting Protein
HIST3H3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIST3H3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HIST3H3.
KDM4A;SFMBT1;H2AFX
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References
- Kurita, H; Schnekenburger, M; et al. The Ah Receptor Recruits IKK alpha to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation. TOXICOLOGICAL SCIENCES 139:121-132(2014).
- Peach, SE; Rudomin, EL; et al. Quantitative Assessment of Chromatin Immunoprecipitation Grade Antibodies Directed against Histone Modifications Reveals Patterns of Co-occurring Marks on Histone Protein Molecules. MOLECULAR & CELLULAR PROTEOMICS 11:128-137(2012).
