HIPK2
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Official Full Name
homeodomain interacting protein kinase 2 -
Overview
HIPK2 is a conserved serine/threonine nuclear kinase that interacts with homeodomain transcription factors. -
Synonyms
HIPK2;homeodomain interacting protein kinase 2;homeodomain-interacting protein kinase 2;hHIPk2;PRO0593;FLJ23711;DKFZp686K02111
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Sf9 Cells
- HEK293
- Insect Cells
- Wheat Germ
- Mammalian Cells
- In Vitro Cell Free System
- Sf21 Cells
- His
- GST
- Myc&DDK
- Flag
- His&Fc&Avi
- Non
Involved Pathway
HIPK2 involved in several pathways and played different roles in them. We selected most pathways HIPK2 participated on our site, such as Wnt Signaling Pathway NetPath, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIPK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt Signaling Pathway NetPath | TAX1BP3,ROR2,NR5A1,ANKRD6,TFAP2A,MTAP1B,BRD7,MARK2,CRYBB2,TCF4 |
Protein Function
HIPK2 has several biochemical functions, for example, ATP binding,NOT DNA binding,RNA polymerase II activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HIPK2 itself. We selected most functions HIPK2 had, and list some proteins which have the same functions with HIPK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | SFMBT1,ZEB1,LHX9,BHLHE40,KCNA3,SKOR1B,DDIT3,CDYL,RELB,BCL11A |
| protein binding | MFF,STX3,SLC3A2,RYK,EPHB6,NMI,CD177,CD74,NR1H4,EZH2 |
| protein serine/threonine kinase activity | PRKCDA,CSNK2A2,RIOK1,CAMK1DB,MAPK11,NEK12,TNNI3K,BMPR1AB,MAP2K4,BMPR1AA |
| transferase activity | FLJ11011L,NADKD1,SULT1ST3,JAK2B,UGT5C3,SULT1ST8,NMT1B,NMT1A,UGT5A5,BMPR2A |
| SMAD binding | SMAD2,USP15,PRDM16,BMP2,STUB1,SKIA,TGFBR3,COL1A2,AXIN1,SOD3 |
| protein kinase activity | AKT1,CSNK1G2B,MAP3K3,LRRK2,DCLK3,RAF1,CAMK1GB,TBRG4,JAK2B,MAP2K2A |
| ATP binding | STK24,RPS6KB2,MERTK,EIF2AK3,LIMK1,HSPA12B,ERCC2,KIF20B,IFIH1,TLK2 |
| virion binding | CD209,PVRL1,PPIA,APCS,HSP90B1,CLEC4M,TSG101,PTX3 |
| nucleotide binding | DNM2A,DHX34,MYEF2,CAMKK1B,DNM2B,MYH11A,RAB1BB,EEF2A.1,PARN,TUBD1 |
Interacting Protein
HIPK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIPK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HIPK2.
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References
- Polonio-Vallon, T; Kirkpatrick, J; et al. Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization. CELL CYCLE 13:115-125(2014).
- Puca, R; Nardinocchi, L; et al. Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs. CELL CYCLE 10:1679-1689(2011).
