HEY1
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Official Full Name
hairy/enhancer-of-split related with YRPW motif 1 -
Overview
This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. -
Synonyms
HEY1;hairy/enhancer-of-split related with YRPW motif 1;hairy/enhancer-of-split related with YRPW motif protein 1;BHLHb31;CHF 2;CHF2;HERP2;HESR 1;HESR1;HRT 1;Basic helix loop helix protein OAF1;Cardiovascular helix loop helix factor 2;Cardiovascular helix loop-helix factor 2;Cardiovascular helix-loop-helix factor 2;CHF-2;Class B basic helix-loop-helix protein 31;Hairy and enhancer of split related protein 1;Hairy and enhancer of split-related protein 1;Hairy enhancer-of-split related with YRPW motif protein 1;Hairy related transcription factor 1;Hairy-related transcription factor 1;Hairy/enhancer of split related with YRPW motif 1;HERP 2;HES related repressor protein 1;HES-related repressor protein 1;HES-related repressor protein 2;HESR-1;HEY 1;HEY1_HUMAN;hHRT1;HRT-1;HRT1;MGC1274;OAF 1;OAF1;basic helix-loop-helix protein OAF1;class B basic
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Mammalian Cell
- E.coli
- HEK293
- Wheat Germ
- HEK293T
- In Vitro Cell Free System
- His
- Myc&DDK
- His&GST
- GST
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HEY1-11841Z | Recombinant Zebrafish HEY1 | Mammalian Cell | Zebrafish | His |
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| HEY1-1539H | Recombinant Human HEY1, His-tagged | E.coli | Human | His |
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| HEY1-260H | Recombinant Human HEY1 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| HEY1-29230TH | Recombinant Human HEY1, His-tagged | E.coli | Human | His | Full L. 1-304 a.a. |
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| HEY1-467H | Recombinant Human HEY1 Protein, GST-His-tagged | E.coli | Human | His&GST |
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| HEY1-4715H | Recombinant Human HEY1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HEY1-5575HCL | Recombinant Human HEY1 293 Cell Lysate | HEK293 | Human | Non |
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| HEY1-5576HCL | Recombinant Human HEY1 293 Cell Lysate | HEK293 | Human | Non |
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| Hey1-1118M | Recombinant Mouse Hey1 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| HEY1-3528HF | Recombinant Full Length Human HEY1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 304 amino acids |
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| HEY1-5722H | Recombinant Human HEY1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
HEY1 involved in several pathways and played different roles in them. We selected most pathways HEY1 participated on our site, such as Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants,Constitutive Signaling by NOTCH1 PEST Domain Mutants,Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HEY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | CCNC,HEY2,HDAC5,ADAM10,HEYL,JAG1,MIB1,JAG2,CDK8,HDAC6 |
| NOTCH1 Intracellular Domain Regulates Transcription | TLE3,TLE4,TLE1,TLE2,TUBB3,HEY2,HEYL |
| Notch-mediated HES/HEY network | ASCL1,CTBP1,RCAN1,HES6,MYOD1,YY1,TLE1,BGLAP,GATA1,GATA6 |
| Delta-Notch Signaling Pathway | CNTF,ASCL1,ZFPM1,HES6,HEY2,TUBB3,SAP30,JAG1,YY1,WDR12 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | HEYL,JAG1,CDK8,HDAC6,MIB1,HDAC5,JAG2,ADAM10,CCNC,HEY2 |
| Heart Development | SMYD1,FOXC2,IRX4,HEY2,TBX5,FOXC1,NKX2-5,GATA6,TBX20,FOXH1 |
| Diseases of signal transduction | TNKS,CUX1,STRA6,RBP4,MYO18A,OPN1MW2,CCNC,RBP1,OPN1SW,RNF43 |
| Disease | CTBP1,KPNA4,DERL2,TH1L,KERA,PSIP1,JAG1,OGN,CTDP1,OPN1LW |
Protein Function
HEY1 has several biochemical functions, for example, microsatellite binding,protein binding,protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HEY1 itself. We selected most functions HEY1 had, and list some proteins which have the same functions with HEY1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | EPAS1,SP100,TLE1,NAB2,SOX8,KAT8,MSX2,DNMT1,NFKBIA,PSMD10 |
| transcription factor activity, RNA polymerase II core promoter sequence-specific | TFAP2B,MAX,NKX3,HEY2,PAX7,MEF2C,SMAD3,HEYL |
| transcription factor activity, protein binding | HEYL,HEY2 |
| microsatellite binding | HEY2,HEYL |
| protein dimerization activity | MYCN,MEF2CA,DNM1,HER2,ARNTL,SIM1A,ARNTL2,NEUROG2,SCXB,SIM1B |
| protein binding | PCMT1,LRRFIP2,ZNF398,XPO1,SNTB2,PLEKHG4,LANCL2,ARHGAP33,UPP2,AEBP2 |
| transcription factor activity, sequence-specific DNA binding | FOXJ1B,SIM1A,DBPA,NEUROD2,NFKB1,TBX1,ZIC1,EGR2B,STAT5A,CREB3L3A |
Interacting Protein
HEY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HEY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HEY1.
SMAD9;SKIL;SMAD3;LAPTM5;PRKD2;PTBP3
HEY1 Related Signal Pathway
Resources
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References
- Campese, AF; Grazioli, P; et al. Mouse Sertoli Cells Sustain De Novo Generation of Regulatory T Cells by Triggering the Notch Pathway Through Soluble JAGGED1. BIOLOGY OF REPRODUCTION 90:-(2014).
- Wang, H; Chen, YL; et al. Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway. MODERN PATHOLOGY 26:139-147(2013).
