HEXA
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Official Full Name
hexosaminidase A (alpha polypeptide) -
Overview
This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). -
Synonyms
HEXA;hexosaminidase A (alpha polypeptide);beta-hexosaminidase subunit alpha;GM2 gangliosidosis;Tay Sachs disease;Beta hexosaminidase alpha chain precursor;Beta hexosaminidase subunit alpha;Beta N acetylhexosaminidase;Beta N acetylhexosaminidase subunit alpha;Beta-N-acetylhexosaminidase subunit alpha;HEXA_HUMAN;Hexosaminidase A alpha polypeptide;Hexosaminidase A;Hexosaminidase subunit A;MGC99608;N acetyl beta glucosaminidase;N acetyl beta glucosaminidase subunit alpha;N-acetyl-beta-glucosaminidase subunit alpha;TSD
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Rat
- Zebrafish
- Insect Cells
- E.coli
- Mammalian Cell
- Wheat Germ
- Insect Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- Non
- GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
HEXA involved in several pathways and played different roles in them. We selected most pathways HEXA participated on our site, such as Other glycan degradation,Amino sugar and nucleotide sugar metabolism,Glycosaminoglycan degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HEXA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amino sugar and nucleotide sugar metabolism | PGM1,UGDH,HK2,GMPPA,CHIA.3,FPGT,GALK1,RENBP,CHIA.4,CYB5R4 |
| Glycosaminoglycan degradation | IDS,SPAM1,ARSB,GLB1,HYAL6,NAGLU,HPSE,HGSNAT,GNS,HYAL4 |
| Other glycan degradation | FUCA1.2,NEU2,MANBA,ENG-1,FUCA1,NEU3.2,HEXB,GBA,MAN2B1,AGA |
| Glycosphingolipid biosynthesis - globo series | NAGA,B3GALT5,HEXB,B3GALNT1,ST3GAL1,GLA,A4GALT,FUT1,FUT2,GBGT1L4 |
| Glycosphingolipid biosynthesis - ganglio series | ST3GAL5,ST3GAL1,B3GALT4,ST8SIA5,SLC33A1,ST6GALNAC4,B4GALNT1,ST6GALNAC5,HEXB,ST8SIA1 |
| Metabolic pathways | PCXB,GLUD1B,NSDHL,NAMPT,RDH8,ACOX1,GUK1A,H6PD,PLA2G10,NDUFA11 |
| Lysosome | AP1S2,ATP6AP1B,LITAF,GGA3,GNPTG,ATP6V0A1A,CTSA,ATP6V0C,LAPTM4A,CTSSB.1 |
Protein Function
HEXA has several biochemical functions, for example, acetylglucosaminyltransferase activity,beta-N-acetylhexosaminidase activity,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HEXA itself. We selected most functions HEXA had, and list some proteins which have the same functions with HEXA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acetylglucosaminyltransferase activity | MGAT1B,B3GNT9-PS,B3GALNT2,GALNT18A,4931440L10Rik,GCNT4A,GLT8D1,XYLT2,UGGT1,DPY19L1 |
| protein heterodimerization activity | OSTB,HIST1H2BL,CHRNB2,HIST1H2BE,IRAK3,NPM1,BAX,MTTP,NR2C2,SOS1 |
| beta-N-acetylhexosaminidase activity | Chil3,HEXDC,HEXB |
Interacting Protein
HEXA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HEXA here. Most of them are supplied by our site. Hope this information will be useful for your research of HEXA.
ABL1;FYN;CRK;USP22;SYNCRIP;cona_canen;Tuba3a;H2AFX;BAG6;Ypel5;HNRNPD;SGTB;CEP170P1;FAN1
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References
- Puhan, D; Bijwe, J; et al. Investigations on Performance Properties of Nano-Micro Composites Based on Polyetherketone, Short Carbon Fibers and Hexa-Boron Nitride. SCIENCE OF ADVANCED MATERIALS 7:1002-1011(2015).
- Srinivas, K; Babu, CN; et al. Thermal, optical and structural properties of disulfide and diselenide salts with weakly associated anions. JOURNAL OF MOLECULAR STRUCTURE 1086:201-206(2015).
