HES7
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Official Full Name
hairy and enhancer of split 7 (Drosophila) -
Overview
This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
HES7;hairy and enhancer of split 7 (Drosophila);transcription factor HES-7;bHLH factor Hes7;bHLHb37;Class B basic helix loop helix protein 37;Class B basic helix-loop-helix protein 37;hairy and enhancer of split 7;HES7_HUMAN;hHes7;Transcription factor HES 7;SCDO4
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HES7-399H | Recombinant Human hes family bHLH transcription factor 7, His-tagged | E.coli | Human | His | 1-230 a.a. |
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| HES7-4707H | Recombinant Human HES7 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HES7-7591M | Recombinant Mouse HES7 Protein | Mammalian Cell | Mouse | His |
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| HES7-3521HF | Recombinant Full Length Human HES7 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 225 amino acids |
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| HES7-4136M | Recombinant Mouse HES7 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| HES7-4136M-B | Recombinant Mouse HES7 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
HES7 involved in several pathways and played different roles in them. We selected most pathways HES7 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HES7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
HES7 has several biochemical functions, for example, DNA binding,protein dimerization activity,transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HES7 itself. We selected most functions HES7 had, and list some proteins which have the same functions with HES7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | PPARG,E2F5,BCL2,HES6,DACT2,NBN,STK4,TRIB2,TRIM11,NLRP3 |
| DNA binding | ZBTB9,SALL3,ZNF654,MCM3AP,DMRT2,JARID2B,ZNF143B,TXLNB,ANKRD1,BLZF1 |
| protein dimerization activity | MESP1,ZBED1,ASCL4,HEY1,AHRRA,HIF1AL2,PPP3CA,PEX3,OLIG1,MYCS |
Interacting Protein
HES7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HES7 here. Most of them are supplied by our site. Hope this information will be useful for your research of HES7.
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References
- Kobayashi, T; Kageyama, R; et al. Expression Dynamics and Functions of Hes Factors in Development and Diseases. BHLH TRANSCRIPTION FACTORS IN DEVELOPMENT AND DISEASE 110:263-283(2014).
- van der Fits, L; Qin, YJ; et al. NOTCH1 Signaling as a Therapeutic Target in Sezary Syndrome. JOURNAL OF INVESTIGATIVE DERMATOLOGY 132:2810-2817(2012).
