HELZ
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Official Full Name
helicase with zinc finger -
Overview
HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding;double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other;proteins (Wagner et al., 1999 (PubMed 10471385)). -
Synonyms
HELZ;helicase with zinc finger;probable helicase with zinc finger domain;DHRC;down regulated in human cancers;HUMORF5;KIAA0054;helicase with zinc finger domain;down-regulated in human cancers protein;DRHC;MGC163454;DKFZp586G1924
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HELZ-12461Z | Recombinant Zebrafish HELZ | Mammalian Cell | Zebrafish | His |
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| HELZ-4685H | Recombinant Human HELZ Protein, GST-tagged | Wheat Germ | Human | GST |
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| HELZ-7570M | Recombinant Mouse HELZ Protein | Mammalian Cell | Mouse | His |
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| HELZ-4120M | Recombinant Mouse HELZ Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| HELZ-4120M-B | Recombinant Mouse HELZ Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
HELZ involved in several pathways and played different roles in them. We selected most pathways HELZ participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HELZ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HELZ has several biochemical functions, for example, ATP binding,helicase activity,hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HELZ itself. We selected most functions HELZ had, and list some proteins which have the same functions with HELZ. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MARVELD3,ERCC2,CORO1A,NKX3,GRIA1,GSK3A,SDCCAG8,NACC2,FAM119A,SND1 |
| ATP binding | UBE2E1,NAV3,EPHB6,FUK,ATP1A2A,KSR2,GLUL,GTF2F2,ATP2A3,TTLL12 |
| hydrolase activity | DUSP19B,MEIOB,PPEF2,DUSP3B,PPM1LA,MRPL46,SSH2B,DDHD2,CLCA5,FURINB |
| poly(A) RNA binding | TSR1,RBBP6,CPEB4,RBFOX2,MRPL10,HIST1H4D,PKM,HSPD1,DBR1,SNRPB |
| helicase activity | NAV2,ZRANB3,WRN,SMARCA5,DNA2,DDX52,SMARCA4,MOV10B.1,CHD1L,DDX51 |
| metal ion binding | ICN2,FHL3B,SPNA1,NDUFS8,MAT1A,TRIM43C,JADE1,PRDM12,ZBTB18,MKNK2 |
| nucleotide binding | FYNA,GMPPAA,GNAO1B,RHOUB,EIF3G,DCLK2,ZFML,ATP2A2B,RABL6,RBM7 |
Interacting Protein
HELZ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HELZ here. Most of them are supplied by our site. Hope this information will be useful for your research of HELZ.
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References
- Zuo, DY; Guo, DD; et al. 3-(3-Hydroxy-4-methoxypheny1)-4-(3,4,5-trimethoxypheny1)-1,2,5selenadiazole (G-1103), a novel combretastatin A-4 analog, induces G2/M arrest and apoptosis by disrupting tubulin polymerization in human cervical HeLa cells and fibrosarcoma HT-1080 cells. CHEMICO-BIOLOGICAL INTERACTIONS 227:7-17(2015).
- Drott, A; Bjorn, E; et al. Refining Thermodynamic Constants for Mercury(II)-Sulfides in Equilibrium with Metacinnabar at Sub-Micromolar Aqueous Sulfide Concentrations. ENVIRONMENTAL SCIENCE & TECHNOLOGY 47:4197-4203(2013).
