HELT
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Official Full Name
helt bHLH transcription factor -
Synonyms
HELT;helt bHLH transcription factor;HES/HEY like transcription factor , Hey like transcription factor (zebrafish);hairy and enhancer of split-related protein HELT;bHLHb44;HCM1228;HES like;HESL;MEGANE;megane bHLH factor;Mgn;Heslike;Megane bHLH
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
HELT involved in several pathways and played different roles in them. We selected most pathways HELT participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HELT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HELT has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HELT itself. We selected most functions HELT had, and list some proteins which have the same functions with HELT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | TEFA,STAT5B,ZFP13,MYCA,ZNF789,OTX1B,ZSCAN23,DMRT3,VAX2,NR6A1A |
| protein homodimerization activity | BNIP3,HHEX,SLC30A8,TMEM173,CD200,JUP,LRRK2,PPP2R4,HOMER2,HPRT1 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | NKX6-2,TBX15,OVOL1,PPARA,ATF7,PROX1A,AEBP2,CTCF,GCFC2,ZFP746 |
| protein dimerization activity | MESPBA,HES6,LYL1,FAP,MSGN1,ASCL5,NHLH1,HER5,TWIST1A,HES4 |
| protein binding | PCSK9,MS4A3,KRTAP23-1,FOSL2,TAX1BP3,GDI1,NOS1AP,SARM1,RTDR1,PHF16 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | HOXC11,SMAD4,MAFB,DLX4,ZFP746,MEOX2,MITF,SMAD3,ZGPAT,ZNF695 |
| DNA binding | ZNF507,PPARA,RORA,ATOH8,ALX4,POLE2,VDRA,CHTF8,IRX5B,HIST1H2BO |
Interacting Protein
HELT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HELT here. Most of them are supplied by our site. Hope this information will be useful for your research of HELT.
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References
- Song, H; Lee, B; et al. Ascl1 and Helt act combinatorially to specify thalamic neuronal identity by repressing Dlxs activation. DEVELOPMENTAL BIOLOGY 398:280-291(2015).
- Chapouton, P; Webb, KJ; et al. Expression of Hairy/enhancer of split Genes in Neural Progenitors and Neurogenesis Domains of the Adult Zebrafish Brain. JOURNAL OF COMPARATIVE NEUROLOGY 519:1748-1769(2011).
