HDAC9
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Official Full Name
histone deacetylase 9 -
Overview
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. -
Synonyms
HDAC9;histone deacetylase 9;HD7;HDAC;HDAC7B;KIAA0744;MITR;histone deacetylase 7B;histone deacetylase 4/5-related protein;MEF-2 interacting transcription repressor (MITR) protein;HD9;HD7b;HDRP;HDAC7;HDAC9B;HDAC9FL;DKFZp779K1053
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Insect Cell
- Sf9 Insect Cell
- Mammalian Cell
- Wheat Germ
- HEK293
- Insect cell
- HEK293T
- In Vitro Cell Free System
- His
- GST
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
HDAC9 involved in several pathways and played different roles in them. We selected most pathways HDAC9 participated on our site, such as Alcoholism,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alcoholism | HIST1H4K,NRAS,HIST1H2BK,H2AFB2,MAPK3,GM14478,HIST1H4N,HIST1H4D,H2AFX,CREB3L1 |
| Viral carcinogenesis | HDAC4,RB1,BAD,LTBR,CCND1,IKBKG,HIST1H4E,TBP,NFKB1,RAC1 |
Protein Function
HDAC9 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific),histone deacetylase activity,NOT histone deacetylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC9 itself. We selected most functions HDAC9 had, and list some proteins which have the same functions with HDAC9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone deacetylase activity | HDAC5,HDAC7,ATXN3L,HDAC2,HDAC3,HDAC4,HDAC10,MTA2,HDAC8,HDAC11 |
| repressing transcription factor binding | TLE4,HDAC4,CTBP1,HDAC1,MYC,SKI,KAT5,HDAC7,PRDM5,NOC2L |
| NAD-dependent histone deacetylase activity (H3-K14 specific) | HDAC6,HDAC1,HDAC2,HDAC9B,HDAC7,HDAC10,HDAC11,HDAC4,HDAC7A,HDAC3 |
| protein deacetylase activity | HDAC5,SIRT1,HDAC1,SIN3A,HDAC3,HDAC10,HDAC4,SIRT2,HDAC2 |
| protein kinase C binding | PARD3,PKP2,TRPV4,GLRX3,FEZ1,TIRAP,HAND2,ADD3,HSPB1,AKT1 |
| metal ion binding | ZDHHC22,CHPF,FAM164C,RNF207,MOB3A,CYP2K22,ATP2A1L,B3GAT2,TIMP3,CYP4A10 |
| histone deacetylase binding | DDX20,BRMS1,MEF2D,BRMS1LA,HDAC3,RELA,CCND1,MAGEA2,SIRT2,NRIP1 |
| protein binding | ZNF397,AIP,PKM,CHIC2,HLX,IMP4,MPPED2,RNF10,GRIA1,TXN2 |
| transcription corepressor activity | AES,TRIM22,NPAT,NAB2,TBL1XR1,CCND1,RUNX1T1,CSDA,SIRT6,ZFPM2 |
Interacting Protein
HDAC9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC9 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC9.
BCL6;USF1;NCOR1;ETV6;FOXP3;FOXP3;YWHAE;MEF2C;tkt1;WNK1;ZC3H11A;TOP1;TPR;RCC1;MKI67;NOP2;ADAR
HDAC9 Related Signal Pathway
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