HCLS1
-
Official Full Name
hematopoietic cell-specific Lyn substrate 1 -
Overview
HS1 (HCLS1, LckBP1, p75) is a protein kinase substrate that is expressed only in tissues and cells of hematopoietic origin. HS1 contains four cortactin repeats and a single SH3 domain. This intracellular protein is phosphorylated following immune receptor -
Synonyms
HCLS1;hematopoietic cell-specific Lyn substrate 1;hematopoietic lineage cell-specific protein;cortactin like;CTTNL;HS1;p75;lckBP1
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Zebrafish
- Mouse
- E. coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- His
- Non
- GST
- N-StrepII and C-His
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
HCLS1 involved in several pathways and played different roles in them. We selected most pathways HCLS1 participated on our site, such as Tight junction,Bacterial invasion of epithelial cells,Pathogenic Escherichia coli infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with HCLS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathogenic Escherichia coli infection | TUBB6,TUBB2B,KRT18,FYN,TUBA4A,TUBA8,ABL1,TUBA3D,WASL,ROCK1 |
| Bacterial invasion of epithelial cells | PIK3R2,VCL,CDC42,WAS,ITGA5,MET,DOCK1,FN1,ARPC1B,RAC1 |
| Tight junction | RHOA,PPP2R1A,CLDNE,TJP2,CLDN1,CLDN20,PPP2R2BB,CLDN11,MYH9A,MYH1E |
| Shigellosis | CDC42,RHOG,DIAPH1,MAPK11,NFKBIB,NFKBIA,MAPK8,CD44,ROCK1,WASF1 |
| Proteoglycans in cancer | GRB2,NANOG,LUM,FZD8,ITGB5,SDC1,NUDT16L1,PDCD4,ITGA2,PIK3R1 |
Protein Function
HCLS1 has several biochemical functions, for example, RNA polymerase II transcription factor binding,SH3 domain binding,actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HCLS1 itself. We selected most functions HCLS1 had, and list some proteins which have the same functions with HCLS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NFASC,P2RY6,PARVG,COX8A,TRIM31,POLD4,IPO11,ANKRD27,ADAR,CHD1 |
| actin binding | GIPC1,SMYHC1,KLHL4,DIAPH3,BAIAP2L1,CAPZA1,S100A4,SNTA1,PXK,NF2B |
| RNA polymerase II transcription factor binding | ID4,MTDH,GATA4,GSC,ZFPM1,MKX,ZFPM2,TAL1,TOX2,GATA2B |
| protein complex binding | SLC27A5,MTAP1B,RPAIN,TWF1,BAG3,ABP1,MYO7A,HTR2A,MTHFR,PPP2R2A |
| protein kinase binding | MLKL,TRIB3,STX1B,SPDYE2,BAG5,MAPK4,MAP3K13,CALM2,CSPG4,LCK |
| SH3 domain binding | INPPL1,PARK2,SH3BGRL2,SHANK1,INPP5D,ITGB1BP2,ILK,WAS,TOM1L1,FMNL3 |
Interacting Protein
HCLS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HCLS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HCLS1.
SH2D4A;WIPF1;TERF1;LYN;Dlg4;Mbp;CASP3;WAS;SYK;cutA;ftsX;q8clc4_yerpe;q8czv1_yerpe;QKI
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