HBG1
-
Official Full Name
hemoglobin, gamma A -
Overview
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5-epsilon -- gamma-G -- gamma-A -- delta -- beta--3 -
Synonyms
HBG1;hemoglobin, gamma A;epsilon 3 globin;hemoglobin, epsilon 1;hemoglobin Y beta-like embryonic chain;hemoglobin Y, beta-like embryonic chain;Hbe1;Hbb-y;Hbg1
Recombinant Proteins
- Human
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Mammalian cells
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
- His&Myc
- Flag
Involved Pathway
HBG1 involved in several pathways and played different roles in them. We selected most pathways HBG1 participated on our site, such as Factors involved in megakaryocyte development and platelet production,Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HBG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hemostasis | MYB,HBBE3,KIF20A,KIF2C,BSG,KLC3,ANXA2A,CEACAM6,PROCR,BA2 |
| Factors involved in megakaryocyte development and platelet production | BA1L,DOCK8,NFE2,VPS45,KIF9,HBB-BH1,HBBE3,DOCK7,H3F3B.1,SH2B3 |
Protein Function
HBG1 has several biochemical functions, for example, heme binding,iron ion binding,oxygen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HBG1 itself. We selected most functions HBG1 had, and list some proteins which have the same functions with HBG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heme binding | CYP1C2,CYP2P9,LPO,CYP2F2,XGB,CYP2P7,NOS1,CYP4V2,HBA1,CYP51A1 |
| iron ion binding | CYP1A2,TMLHE,CYP2H1,CYP4V8,HBB-BH1,CYP2P8,CALR,IRGM1,Scd1,ALOX5A |
| oxygen transporter activity | HBB-BH1,HBQ1,HBE,HBA2,HBAA,XGB,HBAD,HBG2,HBA-X,HBBE1.1 |
| oxygen binding | CYP2X10.2,CYP2X9,CYP2N13,CYP2J2,CYP2AA7,CYP1B1,CBS,HBD,CYP2C8,HBE |
Interacting Protein
HBG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HBG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HBG1.
VCAM1;heme b;HBZ;GABARAPL2;HBG2
Resources
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References
- Colom-Cadena, A; Velarde, R; et al. Management of a caseous lymphadenitis outbreak in a new Iberian ibex (Capra pyrenaica) stock reservoir. ACTA VETERINARIA SCANDINAVICA 56:-(2014).
- Ruhl, CE; Menke, A; et al. Relationship of Hepatitis C Virus Infection With Diabetes in the US Population. HEPATOLOGY 60:1139-1149(2014).
