HARS

  • Official Full Name

    histidyl-tRNA synthetase

  • Overview

    Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.

  • Synonyms

    HARS;histidyl-tRNA synthetase;histidyl-tRNA synthetase, cytoplasmic;histidine tRNA ligase 1;cytoplasmic;EC 6.1.1.21;FLJ20491;HisRS;histidine translase;Histidine tRNA ligase;Histidyl tRNA synthetase;HRS;Human histidyl tRNA synthetase homolog (HO3) mRNA complete cds;OTTHUMP00000159884;OTTHUMP00000223659;OTTHUMP00000223661;OTTHUMP00000223662;OTTHUMP00000223663;OTTHUMP00000223664;OTTHUMP00000224325;histidine-tRNA ligase;histidine--tRNA ligase;histidine tRN

Recombinant Proteins

  • Human
  • Chicken
  • Mouse
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • Insect Cell
  • Insect Cells
  • In Vitro Cell Free System
  • Baculovirus-Insect Cells
  • HEK293
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
HARS-13669H Recombinant Human HARS, GST-tagged E.coli Human GST 1-282a.a.
HARS-3449H Recombinant Human HARS protein, His-tagged E.coli Human His 1-282 aa
HARS-1296C Recombinant Chicken HARS Mammalian Cell Chicken His
HARS-29181TH Recombinant Human HARS, His-tagged E.coli Human His 509 amino acids
HARS-369H Recombinant Human Histidyl-tRNA Synthetase, His-tagged Sf9 Insect Cell Human His
HARS-4580H Recombinant Human HARS Protein, GST-tagged Wheat Germ Human GST
HARS-46H Recombinant Human Histidyl-tRNA synthetase E.coli Human Non
HARS-7483M Recombinant Mouse HARS Protein Mammalian Cell Mouse His
HARS-793H Recombinant Human Histidyl-tRNA Synthetase, His-tagged E.coli Human His
HARS-8209H Recombinant Human HARS protein, His-tagged E.coli Human His Met1~Gln294
HARS-8500Z Recombinant Zebrafish HARS Mammalian Cell Zebrafish His
HARS-770HCL Recombinant Human HARS cell lysate Human Non
HARS-2229H Recombinant Human HARS protein, His-tagged Insect Cell Human His 2-504aa
HARS-2231H Recombinant Human HARS protein, His-tagged Insect Cells Human His Ala2-Cys509
HARS-3412HF Recombinant Full Length Human HARS Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 509 amino acids
HARS-370H Recombinant Human HARS protein (Ala2-Cys509), His-tagged Baculovirus-Insect Cells Human His 2-509 a.a.
HARS-4058M Recombinant Mouse HARS Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
HARS-4058M-B Recombinant Mouse HARS Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    HARS involved in several pathways and played different roles in them. We selected most pathways HARS participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aminoacyl-tRNA biosynthesis DARS2,CARS,VARS,SARS2,GARS,MADD,NARS,IARS,GATC,PET112L

    Protein Function

    HARS has several biochemical functions, for example, ATP binding,histidine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HARS itself. We selected most functions HARS had, and list some proteins which have the same functions with HARS. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ATP2B3A,FAM120B,VPS4A,GLULA,TRAP1,MYO5A,ATP2B1B,HELZ2,RUVBL1,CDK6
    histidine-tRNA ligase activity HARS2

    Interacting Protein

    HARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HARS here. Most of them are supplied by our site. Hope this information will be useful for your research of HARS.

    TRAF6;TNIK;15-deoxy-delta(12,14;ssrna_ug;NEDD8

    Resources

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